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Predicting functions from protein sequences—where are the bottlenecks?

Nature Genetics volume 18, pages 313–318 (1998)Cite this article

Abstract

The exponential growth of sequence data does not necessarily lead to an increase in knowledge about the functions of genes and their products. Prediction of function using comparative sequence analysis is extremely powerful but, if not performed appropriately, may also lead to the creation and propagation of assignment errors. While current homology detection methods can cope with the data flow, the identification, verification and annotation of functional features need to be drastically improved.

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Authors and Affiliations

  1. EMRL, Meyerhofstr.l, 69012 Heidelberg and Max-Delbrück-Center for Molecular Medicine, Berlin-Buck, Germany

    Peer Bork

  2. NCBI, NIH, Bethesda, USA

    Eugene V. Koonin

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  1. Peer Bork
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  2. Eugene V. Koonin
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Correspondence to Peer Bork.

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Bork, P., Koonin, E. Predicting functions from protein sequences—where are the bottlenecks?. Nat Genet 18, 313–318 (1998). https://doi.org/10.1038/ng0498-313

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