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Poly (A) and Poly (U) in Poliovirus Double Stranded RNA

Nature New Biology volume 242, pages 171–174 (1973)Cite this article

Abstract

Poliovirus double stranded RNA (the “replicative form”) contains poly (A) at the 3′-end of the plus (genome-like) strand which is longer than poly (A) found in polio virion RNA. Digestion with 3′-exonuclease, hybridization to labelled poly (A) or poly (U), and affinity chromatography reveal that the minus strand contains 3′-terminal poly (U). These findings may imply that polio RNA replication proceeds through circular structures.

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Authors and Affiliations

  1. Department of Microbiology, St Louis University School of Medicine, St Louis, Missouri, 63104

    YOSHIAKI YOGO & ECKARD WIMMER

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  1. YOSHIAKI YOGO
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  2. ECKARD WIMMER
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YOGO, Y., WIMMER, E. Poly (A) and Poly (U) in Poliovirus Double Stranded RNA. Nature New Biology 242, 171–174 (1973). https://doi.org/10.1038/newbio242171a0

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  • DOI: https://doi.org/10.1038/newbio242171a0

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