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Rotational Diffusion of Rhodopsin in the Visual Receptor Membrane

Nature New Biology volume 236, pages 39–43 (1972)Cite this article

Abstract

Transient photodichroism in the frog retina reveals that rhodopsin has a relaxation time of 20 µs. The site rhodopsin occupies in the membrane must therefore be highly fluid. This suggests rhodopsin may be a diffusional carrier.

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References

  1. Sperling, W., and Rafferty, C. N., Nature, 224, 591 (1969).

    Article  CAS  Google Scholar 

  2. Schmidt, W. J., Kolloidzeitschrift, 85, 137 (1938).

    CAS  Google Scholar 

  3. Denton, E. J., J. Physiol., 124, 17 (1954).

    Article  CAS  Google Scholar 

  4. Liebman, P. A., Biophys. J., 2, 161 (1962).

    Article  CAS  Google Scholar 

  5. Wald, G., Brown, P. K., and Gibbons, I. R., J. Opt. Soc. Amer., 53, 20 (1963).

    Article  CAS  Google Scholar 

  6. Wald, G., Nature, 124, 65 (1934).

    Article  Google Scholar 

  7. Morton, R. A., and Pitt, G. A. J., Biochem. J., 59, 128 (1955).

    Article  CAS  Google Scholar 

  8. Hubbard, R., and Kropf, A., Proc. US Nat. Acad. Sci., 44, 130 (1958).

    Article  CAS  Google Scholar 

  9. Hubbard, R. J., J. Gen. Physiol., 37, 381 (1954).

    Article  CAS  Google Scholar 

  10. Blasie, J. K., Worthington, C. R., and Dewey, M. M., J. Mol. Biol., 39, 407 (1969).

    Article  CAS  Google Scholar 

  11. Stam, C. H., and MacGillavry, C. H., Acta Cry st., 16, 62 (1963).

    Article  CAS  Google Scholar 

  12. Hubbard, R., Bownds, D., and Yoshizawa, T., Cold Spring Harbor Symp. Quant. Biol., 30, 301 (1965).

    Article  CAS  Google Scholar 

  13. Bownds, D., Nature, 216, 1178 (1967).

    Article  CAS  Google Scholar 

  14. Matthews, R. G., Hubbard, R., Brown, P. K., and Wald, G., J. Gen. Physiol., 47, 215 (1963–64).

    Article  CAS  Google Scholar 

  15. DeRobertis, E., J. Biophys. Biochem. Cytol., 2, 319 (1956).

    Article  CAS  Google Scholar 

  16. Hagins, W. A., and Jennings, W. H., Trans. Faraday Soc., 27, 180 (1959).

    Article  CAS  Google Scholar 

  17. Brown, P. K., Biophys. J., 11, 248 (1971).

    Google Scholar 

  18. Brown, P. K., Nature New Biology, 236, 35 (1972).

    Article  CAS  Google Scholar 

  19. Brindley, G. S., Sci. Amer., 209, 85 (1963).

    Article  CAS  Google Scholar 

  20. Pak, W. L., and Helmrich, H. G., Vision Res., 8, 585 (1968).

    Article  CAS  Google Scholar 

  21. Jenkins, S., thesis, Univ. Pennsylvania (1969).

  22. Pratt, D. C., Livingston, R., and Grellmann, K. H., Photochem. Photobiol., 3, 121 (1964).

    Article  CAS  Google Scholar 

  23. Yoshizawa, T., and Wald, G., Nature, 197, 1279 (1963).

    Article  CAS  Google Scholar 

  24. Wald, G., Durrell, J., and St George, R. C. C., Science, 111, 179 (1950).

    Article  CAS  Google Scholar 

  25. Jagger, W. S., and Liebman, P. A., Biophys. J., 10, 59 (1970).

    Google Scholar 

  26. Blasie, J. K., Biophys. J., 10, 51 (1970).

    Google Scholar 

  27. Edsall, J. T., in Proteins, Amino Acids, and Peptides (edit. by Cohn, E. J., and Edsall, J. T.) (Reinhold, New York, 1943).

    Google Scholar 

  28. Tao, T., Biochem. J., 122, No. 5, 54P (1971).

    Article  CAS  Google Scholar 

  29. Wahl, P., Kasai, M., and Changeux, J. P., Europ. J. Biochem., 18, 332 (1971).

    Article  CAS  Google Scholar 

  30. Einstein, A., Ann. Physik., 19, 371 (1906).

    Article  CAS  Google Scholar 

  31. Blaurock, A. E., and Wilkins, M. H. F., Nature, 223, 906 (1969).

    Article  CAS  Google Scholar 

  32. Frye, L. D., and Edidin, M., J. Cell Sci., 7, 319 (1970).

    CAS  PubMed  Google Scholar 

  33. Rand, R. P., J. Gen. Physiol., 52, 173 (1968).

    Article  CAS  Google Scholar 

  34. Katchalsky, A., Kedem, O., Klibansky, C., and deVries, A., in Flow Properties of Blood (edit. by Copley, A. L., and Stainsby, G.) (Pergamon Press, New York, 1960).

    Google Scholar 

  35. Nielsen, N. C., Fleischer, S., and McConnell, D. G., Biochim. Biophys. Acta, 211, 10 (1970).

    Article  CAS  Google Scholar 

  36. Eichberg, J., and Hess, H. H., Experientia, 23, 993 (1967).

    Article  CAS  Google Scholar 

  37. Keith, A., Bulfield, G., and Snipes, W., Biophys. J., 10, 618 (1970).

    Article  CAS  Google Scholar 

  38. Calvin, M., Wang, H. H., Entine, G., Gill, D., Ferruti, P., Harpold, M. A., and Klein, M. P., Proc. US Nat. Acad. Sci., 63, 1 (1969).

    Article  CAS  Google Scholar 

  39. Hubbell, W. L., and McConnell, H. M., Proc. US Nat. Acad. Sci., 61, 12 (1968).

    Article  CAS  Google Scholar 

  40. Hubbell, W. L., and McConnell, H. M., Proc. US Nat. Acad. Sci., 63, 16 (1969).

    Article  CAS  Google Scholar 

  41. Hubbell, W. L., and McConnell, H. M., Proc. US Nat. Acad. Sci., 64, 20 (1969).

    Article  CAS  Google Scholar 

  42. Davson, H., and Danielli, J. F., The Permeability of Natural Membranes, second ed. (Cambridge University Press, Cambridge and New York, 1952).

    Google Scholar 

  43. Stein, W. D., The Movement of Molecules across Cell Membranes, 88 (Academic Press, New York and London, 1967).

    Google Scholar 

  44. Heller, J., and Lawrence, M. A., Biochemistry, 8, 864 (1970).

    Article  Google Scholar 

  45. Vanderkooi, G., and Sundarlingam, M., Proc. US Nat. Acad. Sci., 67, 233 (1970).

    Article  CAS  Google Scholar 

  46. Blasie, J. K., and Worthington, C. R., J. Mol. Biol., 39, 417 (1969).

    Article  CAS  Google Scholar 

  47. Osterhout, W. J. V., Proc. US Nat. Acad. Sci., 21, 125 (1935).

    Article  CAS  Google Scholar 

  48. Wilbrandt, W., and Rosenberg, T., Pharmacol. Rev., 13, 109 (1961).

    CAS  PubMed  Google Scholar 

  49. Hoffman, J. F., J. Gen. Physiol., 54, 343 (1969).

    CAS  PubMed  PubMed Central  Google Scholar 

  50. Landowne, D., and Ritchie, J. M., J. Physiol., 207, 529 (1970).

    Article  CAS  Google Scholar 

  51. Wald, G., Brown, P. K., and Gibbons, I. R., J. Opt. Soc. Amer., 53, 20 (1963).

    Article  CAS  Google Scholar 

  52. Penn, R. D., and Hagins, W. A., Nature, 223, 201 (1969).

    Article  CAS  Google Scholar 

  53. Hagins, W. A., Penn, R. D., and Yoshikami, S., Biophys. J., 10, 380 (1970).

    Article  CAS  Google Scholar 

  54. Korenbrot, J. I., and Cone, R. A., Biophys. J., 11, 45 (1971).

    Google Scholar 

  55. Baylor, D. A., and Fuortes, M. G. F., J. Physiol., 207, 77 (1970).

    Article  CAS  Google Scholar 

  56. Yoshikami, S., and Hagins, W. A., Biophys. J., 11, 47 (1971).

    Article  Google Scholar 

  57. Portzehl, H., Caldwell, P. C., and Ruegg, J. C., Biochim. Biophys. Acta, 79, 581 (1964).

    CAS  Google Scholar 

  58. Hellam, D. C., and Podolsky, R. J., J. Physiol., 209, 807 (1969).

    Article  Google Scholar 

  59. Reuben, J. P., Brandt, P. W., and MacBerman, Fed. Proc., 29, 846A (1970).

    Google Scholar 

Download references

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Authors and Affiliations

  1. Thomas C. Jenkins Department of Biophysics, The Johns Hopkins University, Baltimore, Maryland, 21218

    RICHARD A. CONE

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  1. RICHARD A. CONE
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CONE, R. Rotational Diffusion of Rhodopsin in the Visual Receptor Membrane. Nature New Biology 236, 39–43 (1972). https://doi.org/10.1038/newbio236039a0

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  • DOI: https://doi.org/10.1038/newbio236039a0

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