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Hippo and its mission for growth control

Nature Cell Biology volume 5, pages 853–855 (2003)Cite this article

During development, tissue growth is controlled by coordinated cellular growth and apoptosis. A series of recent papers describes a newly identified Drosophila gene, hippo, that restricts excessive growth during development by both limiting cell cycle progression and promoting susceptibility to apoptosis. Therefore, hippo may coordinate the regulation of cell division and cell death.

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Figure 1: Cell cycle and apoptosis regulation by Hpo–Sav–Wts complex.

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  1. the Howard Hughes Medical Institute and The Rockefeller University, 1230 York Ave., Box 252, New York, 10021, NY, U.S.A.

    Hyung Don Ryoo & Hermann Steller

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  1. Hyung Don Ryoo
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  2. Hermann Steller
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Ryoo, H., Steller, H. Hippo and its mission for growth control. Nat Cell Biol 5, 853–855 (2003). https://doi.org/10.1038/ncb1003-853

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