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Ubiquitin signalling in the NF-κB pathway

Nature Cell Biology volume 7, pages 758–765 (2005)Cite this article

Abstract

The transcription factor NF-κB (nuclear factor kappa enhancer binding protein) controls many processes, including immunity, inflammation and apoptosis. Ubiquitination regulates at least three steps in the NF-κB pathway: degradation of IκB (inhibitor of NF-κB), processing of NF-κB precursors, and activation of the IκB kinase (IKK). Recent studies have revealed several enzymes involved in the ubiquitination and deubiquitination of signalling proteins that mediate IKK activation through a degradation-independent mechanism.

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Figure 1: The NF-κB signalling pathways.
Figure 2: A model for the processing of p100 by the proteasome.
Figure 3: A model for IKK activation by TRAF6 ubiquitination.
Figure 4: A central role for ubiquitin in multiple signalling pathways.

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Acknowledgements

I thank A. Tizenor for excellent graphic illutration. Research in my laboratory is supported by grants from NIH (R01-GM63692), the Welch Foundation (I1389) and the American Cancer Society (RSG0219501TBE). Z.J.C is a Leukemia and Lymphoma Society Scholar and a Burroughs Wellcome Fund Investigator in Pathogenesis of Infectious Diseases.

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  1. Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, 75390-9148, TX, USA

    Zhijian J. Chen

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Chen, Z. Ubiquitin signalling in the NF-κB pathway. Nat Cell Biol 7, 758–765 (2005). https://doi.org/10.1038/ncb0805-758

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