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Cancer

Opening LOX to metastasis

Nature volume 522, pages 41–42 (2015)Cite this article

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New findings implicate the enzyme lysyl oxidase (LOX), secreted by oxygen-deprived breast cancer cells, in inducing bone lesions that precede and facilitate the spread of the cancer cells to the bone. See Letter p.106

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Figure 1: Pre-metastatic niche formation in bone.

Change history

  • 11 May 2023

    The article on which this News & Views commented, ‘The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase’, has now been retracted.

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References

  1. Coleman, R. E., Gregory, W., Marshall, H., Wilson, C. & Holen, I. Breast 22 (Suppl. 2) S50–S56 (2013).

    Article  PubMed  Google Scholar 

  2. Cox, T. R. et al. Nature 522, 106–110 (2015).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  3. Joyce, J. A. & Pollard, J. W. Nature Rev. Cancer 9, 239–252 (2009).

    Article  CAS  Google Scholar 

  4. Erez, N. & Coussens, L. M. Int. J. Cancer 128, 2536–2544 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Gilkes, D. M. & Semenza, G. L. Future Oncol. 9, 1623–1636 (2013).

    Article  CAS  PubMed  Google Scholar 

  6. Barker, H. E., Cox, T. R. & Erler, J. T. Nature Rev. Cancer 12, 540–552 (2012).

    Article  CAS  Google Scholar 

  7. Erler, J. T. et al. Cancer Cell 15, 35–44 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Kaplan, R. N., Rafii, S. & Lyden, D. Cancer Res. 66, 11089–11093 (2006).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Paget, S. Cancer Metast. Rev. 8, 98–101 (1989).

    CAS  Google Scholar 

  10. Witz, I. P. Cancer Res. 68, 9–13 (2008).

    Article  CAS  PubMed  Google Scholar 

  11. McAllister, S. S. & Weinberg, R. A. Nature Cell Biol. 16, 717–727 (2014).

    Article  CAS  PubMed  Google Scholar 

  12. Brown, J. E. & Coleman, R. E. Nature Rev. Clin. Oncol. 9, 110–118 (2012).

    Article  CAS  Google Scholar 

Download references

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  1. Neta Erez is in the Department of Pathology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978 Israel.,

    Neta Erez

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  1. Neta Erez
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Erez, N. Opening LOX to metastasis. Nature 522, 41–42 (2015). https://doi.org/10.1038/nature14529

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