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Biochemistry

Rear view of an enzyme

Nature volume 497, pages 576–577 (2013)Cite this article

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The enzyme Ubc9 mediates attachment of the small modifier protein SUMO to target proteins. It emerges that for optimal functioning — and for proper meiotic cell division — Ubc9 itself must be modified by SUMO.

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Figure 1: Forging a link in the SUMO chain.

Notes

  1. *This News & Views article was published online on 22 May 2013.

References

  1. Gareau, J. R. & Lima, C. D. Nature Rev. Mol. Cell Biol. 11, 861–871 (2010).

    Article  CAS  Google Scholar 

  2. Klug, H. et al. Mol. Cell http://dx.doi.org/10.1016/j.molcel.2013.03.027 (2013).

  3. Bylebyl, G. R., Belichenko, I. & Johnson, E. S. J. Biol. Chem. 278, 44113–44120 (2003).

    Article  CAS  Google Scholar 

  4. Ho, C.-W., Chen, H.-T. & Hwang, J. J. Biol. Chem. 286, 21826–21834 (2011).

    Article  CAS  Google Scholar 

  5. Knipscheer, P. et al. Mol. Cell 31, 371–382 (2008).

    Article  CAS  Google Scholar 

  6. Knipscheer, P., van Dijk, W. J., Olsen, J. V., Mann, M. & Sixma, T. K. EMBO J. 26, 2797–2807 (2007).

    Article  CAS  Google Scholar 

  7. Eddins, M. J., Carlile, C. M., Gomez, K. M., Pickart, C. M. & Wolberger, C. Nature Struct. Mol. Biol. 13, 915–920 (2006).

    Article  CAS  Google Scholar 

  8. Werner, A., Flotho, A. & Melchior, F. Mol. Cell 46, 287–298 (2012).

    Article  CAS  Google Scholar 

  9. Watts, F. Z. & Hoffmann, E. BioEssays 33, 529–537 (2011).

    Article  CAS  Google Scholar 

  10. Hsieh, Y.-L. et al. EMBO J. 32, 791–804 (2013).

    Article  CAS  Google Scholar 

  11. Kelley, J. B. et al. Mol. Cell. Biol. 31, 3378–3395 (2011).

    Article  ADS  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Mary Dasso is in the Program in Cellular Regulation and Metabolism, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA.,

    Mary Dasso

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  1. Mary Dasso
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Correspondence to Mary Dasso.

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Dasso, M. Rear view of an enzyme. Nature 497, 576–577 (2013). https://doi.org/10.1038/nature12249

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