The infectious form of the malaria parasite has thousands of proteins, making it tough to develop a vaccine for it. Narrowing down which proteins cause protective immune responses may help resolve the problem.
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This article and the paper concerned8 were published online on 6 December 2006.
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The author is chief executive of Sanaria Inc., the primary mission of which is to develop a radiation-attenuated P. falciparum sporozoite vaccine.
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Hoffman, S. A protective paradox. Nature 444, 825–827 (2006). https://doi.org/10.1038/nature05409
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DOI: https://doi.org/10.1038/nature05409