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SZGR: a comprehensive schizophrenia gene resource

Molecular Psychiatry volume 15, pages 453–462 (2010)Cite this article

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Abstract

Schizophrenia is a major debilitating psychiatric disorder affecting ∼1% of the population worldwide. A tremendous amount of effort has been expended in the last two decades to identify genes influencing susceptibility to this disorder. Although there is a strong trend toward integrating data obtained from various genetic studies and their related biological information into a comprehensive resource for many complex diseases, we were unable to find such an effort for schizophrenia or for any other psychiatric disorder yet. In this study, we present Schizophrenia gene resource (SZGR), a comprehensive database with user-friendly web interface. SZGR deposits genetic data from all available sources, including those from association studies, linkage scans, gene expression, literature, gene ontology (GO) annotations, gene networks, cellular and regulatory pathways, as well as microRNAs and their target sites. Moreover, SZGR provides online tools for data browse and search, data integration, custom gene ranking and graphical presentation. This system can be easily applied to other complex diseases, especially to other psychiatric disorders. The SZGR database is available at http://bioinfo.mc.vanderbilt.edu/SZGR/.

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Acknowledgements

We thank Drs Kenneth Kendler, Ayman Fanous, Brien Riley, and many other colleagues for their valuable discussions. This work was supported by grants (AA017437 and LM009598) from National Institute of Health, Thomas F and Kate Miller Jeffress Memorial Trust Fund and NARSAD Young Investigator Award to ZZ.

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Authors and Affiliations

  1. Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA

    P Jia, J Sun & Z Zhao

  2. Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA

    P Jia, J Sun & Z Zhao

  3. Virginia Institute for Psychiatric and Behavioral Genetics and Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA

    A Y Guo & Z Zhao

  4. Department of Cancer Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA

    Z Zhao

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  1. P Jia
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  4. Z Zhao
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Correspondence to Z Zhao.

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Supplementary Information accompanies the paper on the Molecular Psychiatry website

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Jia, P., Sun, J., Guo, A. et al. SZGR: a comprehensive schizophrenia gene resource. Mol Psychiatry 15, 453–462 (2010). https://doi.org/10.1038/mp.2009.93

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