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Higher levels of circulating monocyte–platelet aggregates are correlated with viremia and increased sCD163 levels in HIV-1 infection

Cellular & Molecular Immunology volume 12, pages 435–443 (2015)Cite this article

Abstract

Increased levels of monocyte–platelet aggregates (MPAs) are reported to be highly correlated with cardiovascular events. In this study, the MPA levels in different monocyte subsets and the associations between MPA levels, HIV-1 viremia and monocyte activation were evaluated during HIV-1 infection. The results showed that the percentages of MPAs in all three monocyte subsets were higher in HIV-1-infected subjects than in healthy controls, and were associated with the plasma viral load in the non-classical and intermediate monocyte subsets. The plasma levels of sCD14 and sCD163 were upregulated in HIV-1 infection and were positively associated with viral loads and negatively associated with CD4 counts. P-selectin glycoprotein ligand-1 (PSGL-1) was shown to be expressed at significantly lower levels on all three monocyte subsets and was negatively correlated with the sCD163 level. The MPA level was correlated with the levels of plasma sCD163 but negatively correlated with CD163 and PSGL-1 on all three monocyte subsets. An elevated immune activation status was correlated with increased MPA formation, underlying the potential interaction between monocyte activation and MPA formation. This interaction may be related to a higher thromboembolic risk in patients infected with HIV-1.

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Acknowledgements

We thank Jenny Hsi for her critical editing of the manuscript. This work was supported by the National Natural Science Foundation of China (31100126, 81271826, 81020108030, 81101281), SKLID Development grants (2011SKLID207, 2012SKLID103), The China National Major Projects for Infectious Diseases Control and Prevention (2012ZX10001008, 2014ZX10001001-002) and the Beijing Natural Science Foundation (7122108).

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Author notes

  1. Dr T Shen, Department of Microbiology, Peking University Health Science Center, Beijing, 100191, China. E-mail: taoshen@bjmu.edu.cn

  2. Dr YM Shao, State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, China CDC, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing 100026, China. E-mail: yshao08@gmail.com

Authors and Affiliations

  1. State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, China CDC, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing, China

    Hua Liang, Dan Li, Zheng Wang, Li Ren & Yiming Shao

  2. Department of Microbiology, School of Basic Medical Sciences, Peking University, Beijing, China

    Zhaojun Duan & Tao Shen

  3. Beijing Chaoyang District Center for Disease Control and Prevention, Beijing, China

    Dongliang Li

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Liang, H., Duan, Z., Li, D. et al. Higher levels of circulating monocyte–platelet aggregates are correlated with viremia and increased sCD163 levels in HIV-1 infection. Cell Mol Immunol 12, 435–443 (2015). https://doi.org/10.1038/cmi.2014.66

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