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The impact of HIV on naïve T-cell homeostasis

Nature Medicine volume 6, pages 976–977 (2000)Cite this article

Correlational data and mathematical modeling suggest that increased division rate of naïve T cells, not reduced thymic output, lowers the frequency of original thymic emigration among these cells in HIV infected individuals. But are there alternate explanations for these data? (pages 1036–1042)

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Figure 1: Regenerative proliferation and transitional expansion contribute to T-cell turnover. The figure provides a small window in time and space into cellular events occurring in a lymphoid tissue.

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Authors and Affiliations

  1. Dept. of Physiology & Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Israel

    Zvi Grossman

  2. Laboratory of Immunology, NIAID National Institutes of Health, Bldg. 10, Rm. 11N311, Bethesda, 20892, Maryland

    Zvi Grossman & William E. Paul

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  1. Zvi Grossman
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  2. William E. Paul
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Grossman, Z., Paul, W. The impact of HIV on naïve T-cell homeostasis. Nat Med 6, 976–977 (2000). https://doi.org/10.1038/79667

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