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The synaptic vesicle cycle: a cascade of protein–protein interactions

Nature volume 375, pages 645–653 (1995)Cite this article

Abstract

The synaptic vesicle cycle at the nerve terminal consists of vesicle exocytosis with neuro-transmitter release, endocytosis of empty vesicles, and regeneration of fresh vesicles. Of all cellular transport pathways, the synaptic vesicle cycle is the fastest and the most tightly regulated. A convergence of results now allows formulation of molecular models for key steps of the cycle. These developments may form the basis for a mechanistic understanding of higher neural function.

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  1. Department of Molecular Genetics and Howard Hughes Medical Institute, University of Texas Southwestern Medical School, Dallas, Texas, 75235, U.S.A.

    Thomas C. Südhof

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Südhof, T. The synaptic vesicle cycle: a cascade of protein–protein interactions. Nature 375, 645–653 (1995). https://doi.org/10.1038/375645a0

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