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Positional cloning of the mouse obese gene and its human homologue

Nature volume 372, pages 425–432 (1994)Cite this article

Abstract

The mechanisms that balance food intake and energy expenditure determine who will be obese and who will be lean. One of the molecules that regulates energy balance in the mouse is the obese (ob) gene. Mutation ofobresults in profound obesity and type II diabetes as part of a syndrome that resembles morbid obesity in humans. The ob gene product may function as part of a signalling pathway from adipose tissue that acts to regulate the size of the body fat depot.

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Author notes

  1. Jeffrey M. Friedman: To whom correspondence should be addressed.

Authors and Affiliations

  1. Howard Hughes Medical Institute, 1230 york avenue, New York, New York, 10021, USA

    Yiying Zhang, Ricardo Proenca, Marisa Barone, Lori Leopold & Jeffrey M. Friedman

  2. The Rockefeller University, 1230 york avenue, New York, New York, 10021, USA

    Yiying Zhang, Ricardo Proenca, Margherita Maffei, Marisa Barone, Lori Leopold & Jeffrey M. Friedman

Authors
  1. Yiying Zhang
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  2. Ricardo Proenca
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  3. Margherita Maffei
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  4. Marisa Barone
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  5. Lori Leopold
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  6. Jeffrey M. Friedman
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Zhang, Y., Proenca, R., Maffei, M. et al. Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425–432 (1994). https://doi.org/10.1038/372425a0

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  • DOI: https://doi.org/10.1038/372425a0

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