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Signal transduction and regulation in smooth muscle

Nature volume 372, pages 231–236 (1994)Cite this article

An Erratum to this article was published on 29 December 1994

Abstract

Smooth muscle cells in the walls of many organs are vital for most bodily functions, and their abnormalities contribute to a range of diseases. Although based on a sliding-filament mechanism similar to that of striated muscles, contraction of smooth muscle is regulated by pharmacomechanical as well as by electromechanical coupling mechanisms. Recent studies have revealed previously unrecognized contractile regulatory processes, such as G-protein-coupled inhibition of myosin light-chain phosphatase, regulation of myosin light-chain kinase by other kinases, and the functional effects of smooth muscle myosin isoforms. Abnormalities of these regulatory mechanisms and isoform variations may contribute to diseases of smooth muscle, and the G-protein-coupled inhibition of protein phosphatase is also likely to be impor-tant in regulating non-muscle cell functions mediated by cytoplasmic myosin II.

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  1. Department of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, Jordan Hall 449, Charlottesville, Virginia, 22908, USA

    Andrew P. Somlyo & Avril V. Somlyo

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Somlyo, A., Somlyo, A. Signal transduction and regulation in smooth muscle. Nature 372, 231–236 (1994). https://doi.org/10.1038/372231a0

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