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Isolation and characterization of the intracellular MHC class II compartment

Nature volume 369, pages 120–126 (1994)Cite this article

Abstract

An intracellular compartment has been isolated to which MHC class II molecules are transported on their way to the plasma membrane. They arrive with an associated invariant chain which is then proteolytically processed while MHC class II molecules acquire antigenic peptide. These loaded class II molecules then leave the compartment devoid of invariant chain and bound for the plasma membrane. This compartment represents a new stage in the endocytic/ lysosomal pathway.

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Author notes

  1. Jean Pieters: To whom correspondence should be addressed at the Department of Immunology

Authors and Affiliations

  1. Department of Cellular Biochemistry, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands

    Abraham Tulp, Desirée Verwoerd & Jean Pieters

  2. Department of Immunology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands

    Jean Pieters

  3. Zentrum für Molekulare Biologie, University of Heidelberg, Heidelberg, Germany

    Bernhard Dobberstein

  4. Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

    Hidde L. Ploegh

Authors
  1. Abraham Tulp
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  2. Desirée Verwoerd
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  3. Bernhard Dobberstein
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  4. Hidde L. Ploegh
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  5. Jean Pieters
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Tulp, A., Verwoerd, D., Dobberstein, B. et al. Isolation and characterization of the intracellular MHC class II compartment. Nature 369, 120–126 (1994). https://doi.org/10.1038/369120a0

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