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C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation

Nature volume 363, pages 133–140 (1993)Cite this article

Abstract

Vulval differentiation in Caenorhabditis elegans is controlled by intercellular signalling mediated by a receptor tyrosine kinase and a ras gene product. The lin-45 gene encodes a homologue of the raf family of serine/threonine kinases and is necessary for vulval differentiation. The lin-45 raf gene product appears to act downstream of the ras protein in this pathway. A proto-oncogene-mediated signalling pathway may be a common feature of metazoan development.

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Author notes

  1. Min Han and Andy Golden: made equal contribution to this study.

Authors and Affiliations

  1. Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado, 80309-0347, USA

    Min Han & Yuming Han

  2. Howard Hughes Medical Institute, Division of Biology 156–29, California Institute of Technology, Pasadena, California, 91125, USA

    Min Han, Andy Golden & Paul W. Sternberg

Authors
  1. Min Han
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  2. Andy Golden
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  3. Yuming Han
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  4. Paul W. Sternberg
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Han, M., Golden, A., Han, Y. et al. C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation. Nature 363, 133–140 (1993). https://doi.org/10.1038/363133a0

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