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CDlb restricts the response of human CD4−8−T lymphocytes to a microbial antigen

Nature volume 360, pages 593–597 (1992)Cite this article

Abstract

MOLECULES encoded by the human GDI locus on chromosome 1 (ref. 33) are recognized by selected CD4−8− T-cell clones expressing either αβ or γδ T-cell antigen receptors1,2. The known structural resemblance of GDI molecules to antigen-presenting molecules encoded by major histocompatibility complex (MHG) genes on human chromosome 6 (refs 3, 4, 34, 35), suggested that GDI may represent a family of antigen-presenting molecules separate from those encoded in the MHC1,5,6. Here we report that the proliferative and cytotoxic responses of human CD4−8− αβTCR+ T cells specific for Mycobacterium tuberculosis can be restricted by GDlb, one of the four identified protein products of the GDI locus. The responses of these T cells to M. tuberculosis seemed not to involve MHG encoded molecules, but were absolutely dependent on the expression of GDlb by the antigen-presenting cell and involved an antigen processing requirement similar to that seen in MHC class Il-restricted antigen presentation. These results provide, to our knowledge, the first direct evidence for the proposed antigen-presenting function of GDI molecules and suggest that the GDI family plays a role in cell-mediated immunity to microbial pathogens.

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Authors and Affiliations

  1. Lymphocyte Biology Section, Department of Rheumatology/Immunology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, 02115, USA

    Steven Porcelli, Craig T. Morita & Michael B. Brenner

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  1. Steven Porcelli
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  2. Craig T. Morita
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  3. Michael B. Brenner
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Porcelli, S., Morita, C. & Brenner, M. CDlb restricts the response of human CD4−8−T lymphocytes to a microbial antigen. Nature 360, 593–597 (1992). https://doi.org/10.1038/360593a0

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