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Crisscross regulation of cell-type-specific gene expression during development in B. subtilis

Nature volume 355, pages 601–604 (1992)Cite this article

Abstract

Sporulation in Bacillus subtilis is a model for how cells of one type generate other differentiated cell types. During sporulation two cellular compartments arise that differ from each other and from the progenitor cell. Differential gene expression between the two is governed by the successive appearance of four transcription factors whose activities are coordinated in crisscross fashion between the two cells.

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References

  1. Herskowitz, I. Nature 342, 749–757 (1989).

    Article  ADS  CAS  PubMed  Google Scholar 

  2. Gober, J. W., Champer, R., Reuter, S. & Shapiro, L. Cell 64, 381–391 (1991).

    Article  CAS  PubMed  Google Scholar 

  3. Buikema, W. J. & Haselkorn, R. Genes Dev. 5, 321–330 (1991).

    Article  CAS  PubMed  Google Scholar 

  4. Losick, R., Youngman, P. & Piggot, P. J. A. Rev. Genet. 20, 625–669 (1986).

    Article  CAS  Google Scholar 

  5. Piggot, P. J. & Coote, J. G. Bact. Rev. 40, 908–962 (1976).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Moran, C. P. Jr in Regulation of Procaryotic Development (eds Smith, I., Slepecky, R. A. & Setlow, P.) 167–184 (Am, Soc. Microbiolo., Washington DC, 1989).

    Google Scholar 

  7. Stragier, P. & Losick, R. Molec. Microbiol. 4, 1801–1806 (1990).

    Article  CAS  Google Scholar 

  8. Helmann, J. D. & Chamberlin, M. J. A. Rev. Biochem. 57, 839–872 (1988).

    Article  CAS  Google Scholar 

  9. Margolis, P., Driks, A. & Losick, R. Science 254, 562–565 (1991).

    Article  ADS  CAS  PubMed  Google Scholar 

  10. Gholamhoseinian, A. & Piggot, P. J. J. Bact. 171, 5747–5749 (1989).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. De Lencastre, H. & Piggot, P. J. gen. Microbiol. 114, 377–389 (1979).

    Article  CAS  PubMed  Google Scholar 

  12. Fort, P. & Piggot, P. J. J. gen. Microbiol. 130, 2147–2153 (1984).

    CAS  PubMed  Google Scholar 

  13. Piggot, P. J., Curtis, C. A. & DeLancastre, H. J. gen. Microbiol. 130, 2123–2126 (1984).

    CAS  PubMed  Google Scholar 

  14. Schmidt, R. et al. Proc. natn. Acad. Sci. U.S.A. 87, 9221–9225 (1990).

    Article  ADS  CAS  Google Scholar 

  15. Partridge, S. R., Foulger, D. & Errington, J. Molec. Microbiol. 5, 757–767 (1991).

    Article  CAS  Google Scholar 

  16. Errington, J., Fort, P. & Mandetstam, J. FEBS Lett. 188, 184–188 (1985).

    Article  CAS  Google Scholar 

  17. Stragier, P. FEBS Lett. 195, 9–11 (1986).

    Article  CAS  PubMed  Google Scholar 

  18. Sun, D., Stragier, P. & Setlow, P. Genes Dev. 3, 141–149 (1989).

    Article  CAS  PubMed  Google Scholar 

  19. Illing, N. & Errington, J. J. Bact. 173, 3159–3169 (1991).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. LaBell, T. L., Trempy, J. E. & Haldenwang, W. G. Proc. natn. Acad Sci. U.S.A. 84, 1784–1788 (1987).

    Article  ADS  CAS  Google Scholar 

  21. Stragier, P., Bonamy, C. & Karmazyn-Campelli, C. Cell 52, 697–704 (1988).

    Article  CAS  PubMed  Google Scholar 

  22. Trempy, J. E., Morrison-Plummer, J. & Haldenwang, W. G. J. Bact. 161, 340–346 (1985).

    CAS  PubMed  PubMed Central  Google Scholar 

  23. Beall, B. & Lutkenhaus, J. Genes Dev. 5, 447–455 (1991).

    Article  CAS  PubMed  Google Scholar 

  24. Driks, A. & Losick, R. Proc. natn. Acad. Sci. U.S.A. 88, 9934–9938 (1991).

    Article  ADS  CAS  Google Scholar 

  25. Ernngton, J., Foulger, D., Illing, N., Partridge, S. R. & Stevens, C. M. in Genetics and Biotechnology of Bacilli (eds Zukowski, M. M., Ganesan, A. T. & Hoch, J. A.) 257–267 (Academic, San Diego, 1990).

    Book  Google Scholar 

  26. Jonas, R. M., Weaver, E. A., Kenney, T. J., Moran, C. P. Jr & Haldenwang, W. G. J. Bact. 170, 507–511 (1988).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Stragier, P., Bouvier, J., Bonamy, C. & Szulmajster, J. Nature 312, 376–378 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  28. Trempy, J. E., Bonamy, C. Szulmajster, J. & Haldenwang, W. G. Proc. natn. Acad. Sci. U.S.A. 82, 4189–4192 (1985).

    Article  ADS  CAS  Google Scholar 

  29. Jonas, R. M. & Haldenwang, W. G. J. Bact. 171, 5226–5228 (1989).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Carlson, H. C. & Haldenwang, W. G. J. Bact. 171, 2216–2218 (1989).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Sussman, M. D. & Setlow, P. J. Bact. 173, 291–300 (1991).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Sun, D., Cabrera-Martinez, R. M. & Setlow, P. J. Bact. 173, 2977–2984 (1991).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Rong, S., Rosenkrantz, M. S. & Sonenshein, A. L. J. Bact. 165, 771–779 (1986).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Clarke, S., Lopez-Diaz, I. & Mandelstam, J. J. gen. Microbiol. 132, 2987–2994 (1986).

    CAS  PubMed  Google Scholar 

  35. Illing, N. & Errington, J. Molec. Microbiol. 5, 1927–1940 (1991).

    Article  CAS  Google Scholar 

  36. Foulger, D. & Errington, J. Molec. Microbiol. 5, 1363–1373 (1991).

    Article  CAS  Google Scholar 

  37. Zheng, L. & Losick, R. J. molec. Biol. 212, 645–660 (1990).

    Article  CAS  PubMed  Google Scholar 

  38. Karmazyn-Campelli, C., Bonamy, C., Savelli, B. & Stragier, P. Genes Dev. 3, 150–157 (1989).

    Article  CAS  PubMed  Google Scholar 

  39. Kroos, L., Kunkel, B. & Losick, R. Science 243, 526–529 (1989).

    Article  ADS  CAS  PubMed  Google Scholar 

  40. Kunkel, B., Sandman, K., Panzer, S., Youngman, P. & Losick, R. J. Bact. 170, 3513–3522 (1988).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Francesconi, S. C., MacAlister, T. J., Setlow, B. & Setlow, P. J. Bact. 170, 5963–5967 (1988).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Setlow, P. in Regulation of Procaryotic Development (eds Smith, I., Slepecky, R. A. & Setlow, P.) 211–221 (Am. Soc. Microbiol., Washington DC, 1989).

    Google Scholar 

  43. Cutting, S., Panzer, S. & Losick, R. J. molec. Biol. 207, 393–404 (1989).

    Article  CAS  PubMed  Google Scholar 

  44. Sandman, K., Kroos, L., Cutting, S., Youngman, P. & Losick, R. J. molec. Biol. 200, 461–473 (1988).

    Article  CAS  PubMed  Google Scholar 

  45. Cutting, S., Driks, A., Schmidt, R., Kunkel, B. & Losick, R. Genes Dev. 5, 456–466 (1991).

    Article  CAS  PubMed  Google Scholar 

  46. Jonas, R. M., Peters, H. K. III & Haldenwang, W. G. J. Bact. 172, 4178–4186 (1990).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Stragier, P. in Prokaryotic Structure and Function: A New Perspective (eds Mohan, S., Dow C. & Cole, J. A.) 297–310 (Soc. Gen. Microbiol., Cambridge University Press, 1992).

    Google Scholar 

  48. Rather, P. N., Coppolecchia, R., DeGrazia, H. & Moran, C. P. Jr J. Bact. 172, 709–715 (1990).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Stragier, P., Kunkel, B., Kroos, L. & Losick, R. Science 243, 507–512 (1989).

    Article  ADS  CAS  PubMed  Google Scholar 

  50. Kunkel, B., Losick, R. & Stragier, P. Genes Dev. 4, 525–535 (1990).

    Article  CAS  PubMed  Google Scholar 

  51. Sato, T., Samori, Y. & Kobayashi, Y. J. Bact. 172, 1092–1098 (1990).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Kunkel, B., Kroos, L., Poth, H., Youngman, P. & Losick, R. Genes Dev. 3, 1735–1744 (1989).

    Article  CAS  PubMed  Google Scholar 

  53. Stevens, C. M. & Errington, J. Molec. Microbiol. 4, 543–552 (1990).

    Article  CAS  Google Scholar 

  54. Adams, L. F., Brown, K. L. & Whiteley, H. R. J. Bact. 173, 3846–3854 (1991).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Lu, S., Halberg, R. & Kroos, L. Proc. natn. Acad. Sci. U.S.A. 87, 9722–9726 (1990).

    Article  ADS  CAS  Google Scholar 

  56. Cutting, S. et al. Cell 62, 239–250 (1990).

    Article  CAS  PubMed  Google Scholar 

  57. Cutting, S., Roels, S. & Losick, R. J. molec. Biol. 221, 1237–1256 (1991).

    Article  CAS  PubMed  Google Scholar 

  58. Errington, J. Proc. R. Soc. B 244, 117–121 (1991).

    Article  ADS  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Cellular and Developmental Biology, The Biological Laboratories, Harvard University, Cambridge, Massachusetts, 02138, USA

    Richard Losick

  2. Institut de Biologie Physico-Chimique, 13 rue Pierre et Marie Curie, 75005, Paris, France

    Patrick Stragier

Authors
  1. Richard Losick
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  2. Patrick Stragier
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Losick, R., Stragier, P. Crisscross regulation of cell-type-specific gene expression during development in B. subtilis . Nature 355, 601–604 (1992). https://doi.org/10.1038/355601a0

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