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A structural taxonomy of DNA-binding domains

Nature volume 353, pages 715–719 (1991)Cite this article

Abstract

The structures of several classes of DNA-binding domains reveal a variety of designs for recognizing a specific site on DNA.

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References

  1. Pabo, C. O. & Sauer, R. T. An. Rev. Biochem. 53, 293–321 (1984).

    Article  CAS  Google Scholar 

  2. Aggarwal, A. K. & Harrison, S. C. A. Rev. Biochem. 59, 933–969 (1990).

    Article  Google Scholar 

  3. Qian, Y. Q. et al. Cell 59, 573–580 (1989).

    Article  CAS  Google Scholar 

  4. Kissinger, C. R. Liu, B., Martin-Blanco, E., Kornberg, T. B. & Pabo, C. O. Cell 63, 579–590 (1990).

    Article  CAS  Google Scholar 

  5. Kaptein, R., Zuiderweg, E. R. P., Scheek, R. M., Boelens, R. & van Gunsteren, W. F. J. Mol. Biol. 182, 179–182 (1985).

    Article  CAS  Google Scholar 

  6. Jordan, S. R. & Pabo, C. O. Science 242, 893–899 (1988).

    Article  ADS  CAS  Google Scholar 

  7. Mondragón, A., Subbiah, S., Almo, S. C., Drottar, M. & Harrison, S. C. J. molec. Biol. 205, 189–200 (1989).

    Article  Google Scholar 

  8. Weber, I. T. & Steitz, T. A. J. molec. Biol. 198, 314–326 (1987).

    Article  Google Scholar 

  9. Schevitz, R. W., Otwinowski, Z., Joachimiak, A., Lawson, C. L. & Sigler, P. B. Nature 317, 782–786 (1985).

    Article  ADS  CAS  Google Scholar 

  10. Kostrewa, D. et al. Nature 349, 178–180 (1991).

    Article  ADS  CAS  Google Scholar 

  11. Wharton, R., Brown, E. L. & Ptashne, M. Cell 38, 361–369 (1984).

    Article  CAS  Google Scholar 

  12. Otting, G. et al. EMBO J. 9, 3085–3092 (1990).

    Article  CAS  Google Scholar 

  13. Pabo, C. O. et al. Science 247, 1210–1213 (1990).

    Article  ADS  CAS  Google Scholar 

  14. Kelleher, C. A., Goutte, C. & Johnson, A. D. Cell 53, 927–936 (1988).

    Article  Google Scholar 

  15. Hanes, S. D. & Brent, R. Cell 57, 1275–1283 (1989).

    Article  CAS  Google Scholar 

  16. Miller, J., McLachlan, A. D. & Klug, A. EMBO J. 4, 1609–1614 (1985).

    Article  CAS  Google Scholar 

  17. Brown, R. S., Sander, C. & Argos, P. FEBS Lett 186, 271–274 (1985).

    Article  CAS  Google Scholar 

  18. Freedman, L. P. et al. Nature 334, 543–546 (1988).

    Article  ADS  CAS  Google Scholar 

  19. Pan, T. & Coleman, J. E. Proc. natn. Acad. Sci. U.S.A. 87, 2077–2081 (1990).

    Article  ADS  CAS  Google Scholar 

  20. Jacobs, G. & Michaels, G. New Biologist 2, 583–584 (1990).

    CAS  PubMed  Google Scholar 

  21. Berg, J. M. Proc. natn. Acad. Sci. U.S.A. 85, 99–102 (1988).

    Article  ADS  CAS  Google Scholar 

  22. Lee, M. S., Gippert, G. P., Soman, K. V., Case, D. A. & Wright, P. E. Science 245, 635–637 (1989).

    Article  ADS  CAS  Google Scholar 

  23. Klevit, R., Herriott, J. R. & Horvath, S. J. Proteins 7, 215–226 (1990).

    Article  CAS  Google Scholar 

  24. Pavletich, N. P. & Pabo, C. O. Science 252, 809–817 (1991).

    Article  ADS  CAS  Google Scholar 

  25. Nardelli, J., Gibson, T. J., Vesque, C. & Charnay, P. Nature 349, 175–178 (1991).

    Article  ADS  CAS  Google Scholar 

  26. Härd, T. et al. Science 249, 157–160 (1990).

    Article  ADS  Google Scholar 

  27. Schwabe, J. W. R., Neuhaus, D. & Rhodes, D. Nature 348, 458–461 (1990).

    Article  ADS  CAS  Google Scholar 

  28. Luisi, B. et al. Nature 352, 497–505 (1991).

    Article  ADS  CAS  Google Scholar 

  29. Umesono, K. & Evans, R. M. Cell 57, 1139–1146 (1989).

    Article  CAS  Google Scholar 

  30. Mader, S., Kumar, V., deVerneuil, H. & Chambon, P. Nature 338, 271–274 (1989).

    Article  ADS  CAS  Google Scholar 

  31. Danielson, M., Hinck, L. & Ringold, G. M. Cell 57, 1131–1138 (1989).

    Article  Google Scholar 

  32. Johnston, M. Microbiol. Rev. 51, 458–476 (1987).

    CAS  PubMed  PubMed Central  Google Scholar 

  33. Carey, M., Kakidani, H., Leatherwood, J., Mostashari, F. & Ptashne, M. J. molec. Biol. 209, 423–432 (1989).

    Article  CAS  Google Scholar 

  34. Bram, R. & Kornberg, R. Proc. natn. Acad. Sci. U.S.A. 82, 43–47 (1985).

    Article  ADS  CAS  Google Scholar 

  35. Giniger, E., Varnum, S. M. & Ptashne, M. Cell 40, 767–774 (1985).

    Article  CAS  Google Scholar 

  36. Orkin, S. H. Cell 63, 665–672 (1990).

    Article  CAS  Google Scholar 

  37. Summers, M. F., South, T. L., Kim, B. & Hare, D. R. Biochemistry 29, 329–340 (1990).

    Article  CAS  Google Scholar 

  38. Frankel, A. D., Bredt, D. S. & Pabo, C. O. Science 249, 70–73 (1988).

    Article  ADS  Google Scholar 

  39. Pelham, H. R. B. & Brawn, D. D. Proc. natn. Acad. Sci. U.S.A. 77, 4170–4174 (1980).

    Article  ADS  CAS  Google Scholar 

  40. You, Q. & Romaniuk, P. J. Nucleic Acids Res. 18, 5055–5062 (1990).

    Article  CAS  Google Scholar 

  41. Landschulz, W. H., Johnson, P. F. & McKnight, S. L. Science 240, 1759–1764 (1988).

    Article  ADS  CAS  Google Scholar 

  42. O'Shea, E. K., Rutkowski, R. & Kim, P. S. Science 243, 538–542 (1989).

    Article  ADS  CAS  Google Scholar 

  43. Oas, T. G., Mclntosh, L. P., O'Shea, E. Dalquist, F. W. & Kim, P. S. Biochemistry 29, 2891–2994 (1990).

    Article  CAS  Google Scholar 

  44. Shuman, J. D., Vinson, C. R. & McKnight, S. L. Science 249, 771–774 (1990).

    Article  ADS  CAS  Google Scholar 

  45. O'Shea, E. K., Rutkowski, R., Stafford, W. F. & Kim, P. S. Science 245, 646–648 (1989).

    Article  ADS  CAS  Google Scholar 

  46. Talanian, R. V., McKnight, C. J. & Kim, P. S. Science 249, 769–771 (1990).

    Article  ADS  CAS  Google Scholar 

  47. O'Neil, K. T., Hoess, R. H. & DeGrado, W. F. Science 249, 775–778 (1990).

    Article  ADS  Google Scholar 

  48. Weiss, M. A. et al. Nature 347, 575–578 (1990).

    Article  ADS  CAS  Google Scholar 

  49. Weiss, M. A. Biochemistry 29, 8020–8024 (1990).

    Article  CAS  Google Scholar 

  50. Patel, L., Abate, C. & Curran, T. Nature 347, 572–574 (1990).

    Article  ADS  CAS  Google Scholar 

  51. Hill, D. E., Hope, I. A., Macke, J. P. & Struhl, K. Science 234, 451–457 (1986).

    Article  ADS  CAS  Google Scholar 

  52. Lee, W., Haslinger, A. Karin, M. Tjian, R. Nature 325, 368–372 (1987).

    Article  ADS  CAS  Google Scholar 

  53. Hai, T., Liu, F., Allegretto, E. A., Karin, M. & Green, M. Genes Dev. 2, 1216–1226 (1988).

    Article  CAS  Google Scholar 

  54. Oakley, M. G. & Dervan, P. B. Science 248, 847–850 (1990).

    Article  ADS  CAS  Google Scholar 

  55. Nye, J. A. & Graves, B. J. Proc. natn. Acad. Sci. U.S.A. 87, 3992–3996 (1990).

    Article  ADS  CAS  Google Scholar 

  56. Gartenberg, M. R. et al. Proc. natn. Acad. Sci. U.S.A. 87, 6034–6038 (1990).

    Article  ADS  CAS  Google Scholar 

  57. Vinson, C. R., Sigler, P. B. & McKnight, S. L. Science 246, 911–916 (1989).

    Article  ADS  CAS  Google Scholar 

  58. Phillips, S. E. V. Curr. Opin. Struct. Biol. 1, 89–98 (1991).

    Article  CAS  Google Scholar 

  59. Rafferty, J. B., Somers, W. S., Saint-Girons, I. & Phillips, S. E. V. Nature 341, 705–710 (1989).

    Article  ADS  CAS  Google Scholar 

  60. Berg, J. N., van Opheusden, J. H. J., Burgering, M. J. M., Boelens, R. & Kaptein, R. Nature 346, 586–589 (1990).

    Article  ADS  Google Scholar 

  61. Phillips, S. E. V. et al. Nature 341, 711–714 (1989).

    Article  ADS  CAS  Google Scholar 

  62. Tanaka, I., Appelt, K., Dijk, J. White, S. W. & Wilson, K. S. Nature 310, 376–381 (1984).

    Article  ADS  CAS  Google Scholar 

  63. White, S. W., Appelt, K., Wilson, K. S. & Tanaka, I. Proteins 5, 281–288 (1989).

    Article  CAS  Google Scholar 

  64. Yang, C-C. & Nash, H. W. Cell 57, 869–880 (1989).

    Article  CAS  Google Scholar 

  65. Murre, C., McCaw, P. S. & Baltimore, D. Cell 56, 777–783 (1989).

    Article  CAS  Google Scholar 

  66. Sorger, P. K. & Nelson, H. C. M. Cell 59, 807–813 (1989).

    Article  CAS  Google Scholar 

  67. Arthur, A. K., Hoess, A. & Fanning, E. J. Virol. 62, 1999–2006 (1988).

    CAS  PubMed  PubMed Central  Google Scholar 

  68. McBride, A. A., Schlegel, R. & Howley, P. M. EMBO J. 7, 533–539 (1988).

    Article  CAS  Google Scholar 

  69. Kieran, M. et al. Cell 62, 1007–1018 (1990).

    Article  CAS  Google Scholar 

  70. Hahn, S., Buratowski, S., Sharp, P. A. & Guarente, L. Cell 58, 1173–1181 (1989).

    Article  CAS  Google Scholar 

  71. Pabo, C. O. & Lewis, M. L. Nature 298, 443–447 (1982).

    Article  ADS  CAS  Google Scholar 

  72. Aggarwal, A. K., Rodgers, D. W., Drottar, M., Ptashne, M. & Harrison, S. Science 242, 899–907 (1988).

    Article  ADS  CAS  Google Scholar 

  73. Mondragón, A., Wolberger, C. & Harrison, S. C. J. molec. Biol. 205, 179–188 (1989).

    Article  Google Scholar 

  74. Mondragón, A. & Harrison, S. C. J. molec. Biol. 219, 321–334 (1991).

    Article  Google Scholar 

  75. Anderson, W. F., Ohlendorf, D. H., Takeda, Y. & Matthews, B. W. Nature 290, 744–749 (1981).

    Article  ADS  Google Scholar 

  76. Brennan, R. G., Roderick, S. L., Takeda, Y. & Matthews, B. W. Proc. natn. Acad. Sci. U.S.A. 87, 8165–8169 (1990).

    Article  ADS  CAS  Google Scholar 

  77. Schultz, S. C. Shields, G. C. & Steitz, T. A. Science 253, 1001–1007 (1991).

    Article  ADS  CAS  Google Scholar 

  78. Otwinowski, Z. et al. Nature 335, 321–329 (1988).

    Article  ADS  CAS  Google Scholar 

  79. Kerppola, T. K. & Curran, T. Current Opinions in Structural Biology 1, 71–79 (1991).

    Article  CAS  Google Scholar 

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  1. Howard Hughes Medical Institute and Department of Biochemistry and Molecular Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts, 02138, USA

    Stephen C. Harrison

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Harrison, S. A structural taxonomy of DNA-binding domains. Nature 353, 715–719 (1991). https://doi.org/10.1038/353715a0

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