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The hunting of the Src

Nature Reviews Molecular Cell Biology volume 2, pages 467–475 (2001)Cite this article

Abstract

The non-receptor tyrosine kinase Src is important for many aspects of cell physiology. The viral src gene was the first retroviral oncogene to be identified, and its cellular counterpart was the first proto-oncogene to be discovered in the vertebrate genome. Src has been important, not only as an object of study in itself, but also as an entry point into the molecular genetics of cancer.

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Figure 1: Memorial symposium in honour of Teruko Hanafusa.
Figure 2: Comparison between v-Src and c-Src.
Figure 3: Activation of c-Src.
Figure 4: Signalling by Src.
Figure 5: Regulation of c-Src by surface receptors.

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Acknowledgements

I thank S. Taylor, M. Botchan, J. Brugge and T. Hunter for helpful comments on the manuscript.

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Authors and Affiliations

  1. Department of Molecular and Cell Biology, University of California, 401 Barker Hall #3204, Berkeley, 94720-3204, California, USA

    G. Steven Martin

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DATABASE LINKS

c-src

EGFR

Csk

Fps

crk

phospholipase Cγ

Hck

annexin II

FAK

Cas

Shc

Stat3

MAPK

MEK

JAK

Btk

PDGF

c-myc

fibrinogen

osteopetrosis

Lck

Blk

Fgr

Lyn

Yes

β-adrenergic receptor

TRANCE

PTPα

progesterone receptor

p190

paxillin

cortactin

β-catenin

p120

plakoglobin

FURTHER INFORMATION

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Martin, G. The hunting of the Src. Nat Rev Mol Cell Biol 2, 467–475 (2001). https://doi.org/10.1038/35073094

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  • DOI: https://doi.org/10.1038/35073094

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