Abstract
There is widespread agreement that mitochondria have a function in apoptosis, but the mechanisms behind their involvement remain controversial. Here we suggest that opening of a multiprotein complex called the mitochondrial permeability transition pore complex is sufficient (and, usually, necessary) for triggering apoptosis.
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Acknowledgements
The authors' work is supported by a special grant from the Ligue Nationale contre le Cancer, as well as grants from ANRS, FRM and EC (to G.K.).
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Zamzami, N., Kroemer, G. The mitochondrion in apoptosis: how Pandora's box opens. Nat Rev Mol Cell Biol 2, 67–71 (2001). https://doi.org/10.1038/35048073
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DOI: https://doi.org/10.1038/35048073
