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Protein function in the post-genomic era

Nature volume 405, pages 823–826 (2000)Cite this article

Abstract

Faced with the avalanche of genomic sequences and data on messenger RNA expression, biological scientists are confronting a frightening prospect: piles of information but only flakes of knowledge. How can the thousands of sequences being determined and deposited, and the thousands of expression profiles being generated by the new array methods, be synthesized into useful knowledge? What form will this knowledge take? These are questions being addressed by scientists in the field known as ‘functional genomics’.

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Figure 1: Two functional protein networks.
Figure 2: The evolution of the meaning of protein function.

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Authors and Affiliations

  1. Molecular Biology Institute and UCLA-DOE Laboratory of Structural Biology and Molecular Medicine, Box 951570, University of California at Los Angeles, Los Angeles, 90095-1570, California , USA

    David Eisenberg, Edward M. Marcotte, Ioannis Xenarios & Todd O. Yeates

Authors
  1. David Eisenberg
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  2. Edward M. Marcotte
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  3. Ioannis Xenarios
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  4. Todd O. Yeates
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Correspondence to David Eisenberg.

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Eisenberg, D., Marcotte, E., Xenarios, I. et al. Protein function in the post-genomic era. Nature 405, 823–826 (2000). https://doi.org/10.1038/35015694

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