Abstract
Experiments analysing the statistical properties of synaptic transmission, before and after the induction of long-term potentiation (LTP), suggest that expression of LTP largely arises in a presynaptic mechanism—an increased probability of transmitter release.
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References
Bliss, T. V. P. & Lomo, T. J. Physiol., Lond. 232, 331–356 (1973).
Bliss, T. V. P. & Lynch, M. in Long-Term Potentiation: From Biophysics to Behavior (eds Landfield, P. W. & Deadwyler, S. A.) 3–72 (Liss, New York, 1988).
Wigstrom, H., Gustafsson, B., Huang, Y.-Y. & Abraham, W. C. Acta physiol. scand. 126, 317–319 (1986).
Kelso, S. R., Ganong, A. H. & Brown, T. H. Proc. natn. Acad. Sci. U.S.A. 83, 5326–5330 (1986).
Malinow, R. & Miller, J. P. Nature 320, 529–530 (1986).
Sastry, B. R., Goh, J. W. & Auyeung, A. Science 232, 988–990 (1986).
Collingridge, G. L. & Bliss, T. V. P. Trends Neurosci. 10, 288–293 (1987).
Gustafsson, B. & Wigstrom, H. Trends Neurosci. 11, 156–162 (1988).
Skrede, K. K. & Malthe-Sorenssen, D. Brain Res. 208, 436–441 (1981).
Dolphin, A. C., Errington, M. L. & Bliss, T. V. P. Nature 297, 496–498 (1982).
Muller, D., Joly, M. & Lynch, G. Science 242, 1694–1697 (1988).
Kauer, J. A., Malenka, R. C. & Nicoll, R. A. Neuron 1, 911–917 (1988).
Davies, S. N., Lester, R. A. J., Reymann, K. G. & Collingridge, G. L. Nature 338, 500–503 (1989).
Del Castillo, J. & Katz, B. J. Physiol., Lond. 124, 560–573 (1954).
Redman, S. J. Physiol. Rev. 70, 165–198 (1990).
Sayer, R. J., Redman, S. J. & Andersen, P. J. Neurosci. 9, 840–850 (1989).
Rall, W. & Segev, I. in Voltage and Patch Clamping with Microelectrodes (eds T. G. Smith et al.) 191–215 (American Physiological Society, Bethesda, 1985).
Brown, T. H., Wong, R. K. S. & Prince, D. A. Brain Res. 174, 194–199 (1979).
Yamamoto, C. Expl Brain Res. 46, 170–176 (1982).
Bekkers, J. M., Richerson, G. B. & Stevens, C. F. Proc. natn. Acad. Sci. U.S.A. 87, 5359–5362 (1990).
Bekkers, J. M. & Stevens, C. F. Nature 341, 230–233 (1989).
Voronin, L. L. in Synaptic Plasticity in the Hippocampus (eds Haas, H. L. & Buzsaki, G.) 27–30 (Springer, Berlin, 1988).
Foster, T. C. & McNaughton, B. L. Soc. Neurosci. Abstr. 15, 775 (1989).
Horn, R. & Marty, A. J. gen. Physiol. 92, 145–159 (1988).
Hamill, O. P. et al. Pflugers Arch. 391, 85–100 (1981).
Forsythe, I. D., Westbrook, G. L. & Mayer, M. L. J. Neurosci. 8, 3733–3741 (1988).
Edwards, F. A., Konnerth, A., Sakmann, B. & Takahashi, T. Pflugers Arch. 414, 600–612 (1989).
Blanton, M. G., Lo Turco, J. J. & Kriegstein, A. R. J. Neurosci. Meth. 30, 203–210 (1989).
Bekkers, J. M. & Stevens, C. F. Progr. Brain Res. 83, 37–45 (Elsevier, Amsterdam, 1990).
Piomelli, D. et al. Nature 328, 38–43 (1987).
Williams, J. H., Errington, M. L., Lynch, M. A. & Bliss, T. V. P. Nature 341, 739–742 (1989).
Manilow, R. & Tsien, R. W. Nature 346, 177–180 (1990).
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Bekkers, J., Stevens, C. Presynaptic mechanism for long-term potentiation in the hippocampus. Nature 346, 724–729 (1990). https://doi.org/10.1038/346724a0
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DOI: https://doi.org/10.1038/346724a0