Abstract
External signals that control the activity of proteins encoded by the ras proto-oncogenes have not previously been characterized. It is now shown that stimulation of the antigen receptor of T lymphocytes causes a rapid activation of p21ras. The mechanism seems to involve a decrease in the activity of GAP, the GTPase-activating protein, on stimulation of protein kinase C. In lymphocytes, p21ras may therefore be an important mediator of the action of protein kinase C.
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References
Barbacid, M. A. Rev. Biochem. 56, 779–827 (1987).
Satoh, T., Endo, M., Nakamura, S. & Kaziro, Y. FEBS Lett. 236, 185–189 (1988).
Satoh, T., Nakamura, S. & Kaziro, Y. Molec. cell. Biol. 7, 4553–4556 (1987).
Field, J., Broek, D., Kataoka, T. & Wigler, M. Molec. cell. Biol. 7, 2128–2133 (1987).
Sweet, R. W. et al. Nature 311, 273–275 (1984).
Der, C. J., Pan, B. T. & Cooper, G. M. Molec. cell. Biol. 6, 3291–3294 (1986).
Trahey, M. & McCormick, F. Science 238, 542–545 (1987).
Cantrell, D. A., Davies, A. A. & Crumpton, M. J. Proc. natn. Acad. Sci. U.S.A. 82, 8158–8162 (1985).
Gillis, S. & Watson, J. Immunol. Rev. 54, 81–109 (1981).
Weiss, A. & Imboden, J. B. Adv. Immun. 41, 1–38 (1987).
Beverley, P. C. L. & Callard, R. E. Eur. J. Immun. 11, 329–334 (1981).
Brattsand, G., Cantrell, D. A., Ward, S., Ivars, F. & Gulberg, M. J. Immun. 144, 3651–3658 (1990).
Rodriguez-Pena, A. & Rozengurt, E. EMBO J. 5, 77–83 (1986).
Graves, J. D., Lucas, S. C., Alexander, D. R. & Cantrell, D. A. Biochem. J. 265, 407–413 (1990).
Wolfman, A. & Macara, I. Science 248, 67–69 (1990).
West, M., Kung, H. & Kamata, T. FEBS Lett. 259, 245–248 (1990).
Downward, J., Riehl, R., Wu, L. & Weinberg, R. A. Proc. natn. Acad. Sci. U.S.A. (in the press).
Ballester, R., Furth, M. E. & Rosen, O. M. J. biol. Chem. 262, 2688–2695 (1987).
Molloy, C. J. et al. Nature 342, 711–714 (1989).
Ellis, C., Moran, M., McCormick, F. & Pawson, T. Nature 343, 377–381 (1990).
Downward, J., de Gunzburg, J., Riehl, R. & Weinberg, R. A. Proc. natn. Acad. Sci. U.S.A. 85, 5774–5778 (1988).
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Downward, J., Graves, J., Warne, P. et al. Stimulation of p21ras upon T-cell activation. Nature 346, 719–723 (1990). https://doi.org/10.1038/346719a0
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DOI: https://doi.org/10.1038/346719a0
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