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Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor ceil

Nature volume 333, pages 560–562 (1988)Cite this article

Abstract

The mitogens which modulate cell–cell interactions during development of the central nervous system are unknown. One of the few interactions sufficiently well understood to allow identification of such molecules involves the two glial lineages which make up the rat optic nerve. One population of glial cells in this tissue, the type-1 astrocytes1, secrete a soluble factor(s) which promotes division of a second population of bipotential oligoden-drocyte/type-2 astrocyte (O-2A) progenitor cells2; these progenitors give rise to oligodendrocytes, which myelinate large axons in the CNS, and type-2 astrocytes, which enwrap bare axons at nodes of Ranvier3,4. Type-1 astrocytes also promote progenitor motility5, and inhibit the premature differentiation of progenitors into oligodendrocytes which occur when these cells are grown in the absence of type-1 astrocytes2,3. We have now found that platelet-derived growth factor mimics the effects of type-1 astrocytes on O-2A progenitor cells, and antibodies to PDGF block the effects of type-1 astrocytes.

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Authors and Affiliations

  1. Ludwig Institute for Cancer Research, 91 Riding House Street, London, W1P 8BT, UK

    Mark Noble, Paul Stroobant & Michael D. Waterfield

  2. Institut Merieux, 69260, Charbonniers les Bains, Lyon, France

    Kerren Murray

  3. Imperial Cancer Research Fund, Lincolns Inn Fields, London, WC2A3PX, UK

    Peter Riddle

Authors
  1. Mark Noble
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  2. Kerren Murray
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  3. Paul Stroobant
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  4. Michael D. Waterfield
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  5. Peter Riddle
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Noble, M., Murray, K., Stroobant, P. et al. Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor ceil. Nature 333, 560–562 (1988). https://doi.org/10.1038/333560a0

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