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The hepatitis B virus

Nature volume 317, pages 489–495 (1985)Cite this article

Abstract

DNA recombinant technology has radically changed hepatitis B virus (HBV) virology. The genetic organization, transcription and replication of the virus are basically understood, structures of integrated HBV sequences in hepatocellular carcinoma have been characterized, and new vaccines produced by recombinant DNA technique are being developed.

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References

  1. Beasley, R. P. & Hwang, L. Y. in Viral Hepatitis and Liver Disease (ed. Vyas, G. N.) 209–224 (Grune & Stratton, New York, 1984).

    Google Scholar 

  2. Chisari, F. V. (ed.) Advances in Hepatitis Research (Masson, New York, 1984).

  3. Robinson, W. S., Marion, P., Feitelson, M. & Siddiqui, A. in Viral Hepatitis 1981 int. Symp. (eds Szmuness, W., Alter, H. J. & Maynard, J. E.) 57–68 (Franklin Institute Press, Philadelphia, 1982).

    Google Scholar 

  4. Summers, J., Smolec, J. & Snyder, R. Proc. natn. Acad. Sci. U.S.A. 75, 4533–4537 (1978).

    Article  ADS  CAS  Google Scholar 

  5. Marion, P. L., Oshiro, L. S., Regnery, D. C., Scullard, G. H. & Robinson, W. S. Proc. natn. Acad. Sci. U.S.A. 77, 2941–2945 (1980).

    Article  ADS  CAS  Google Scholar 

  6. Mason, W. S., Seal, G. & Summers, J. J. Virol. 35, 829–836 (1980).

    Google Scholar 

  7. Couroucé-Pauty, A. M., Plancon, A. & Soulier, J. P. Vox Sang. 44, 197–211 (1983).

    PubMed  Google Scholar 

  8. Stibbe, W. & Gerlich, W. H. J. Virol. 46, 626–628 (1983).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Heermann, K. H. et al. J. Virol. 52, 396–402 (1984).

    CAS  PubMed  PubMed Central  Google Scholar 

  10. Tiollais, P., Wain-Hobson, S. in Advances in Hepatitis Research (ed. Chisari, F. V.) 9–20 (Masson, New York, 1984).

    Google Scholar 

  11. Mishiro, S. et al. J. Immun. 124, 1589–1593 (1980).

    CAS  PubMed  Google Scholar 

  12. Peterson, D. L., Nath, N. & Gavilanes, F. J. biol. Chem. 257, 10414–10420 (1982).

    CAS  PubMed  Google Scholar 

  13. Lerner, R. A. et al. Proc. natn. Acad. Sci. U.S.A. 78, 3403–3407 (1981).

    Article  ADS  CAS  Google Scholar 

  14. Dreesman, G. R. et al. Nature 295, 158–160 (1982).

    Article  ADS  CAS  PubMed  Google Scholar 

  15. Prince, A. M., Ikram, H. & Hopp, T. P. Proc. natn. Acad. Sci. U.S.A. 79, 579–582 (1982).

    Article  ADS  CAS  Google Scholar 

  16. Bhatnagar, P. K. et al. Proc. natn. Acad. Sci. U.S.A. 79, 4400–4404 (1982).

    Article  ADS  CAS  Google Scholar 

  17. Neurath, A.R., Kent, S.B.H. & Strick, N. Proc. natn. Acad. Sci. U.S.A. 79, 7871–7875 (1982).

    Article  ADS  CAS  Google Scholar 

  18. Gerin, J. L. et al. Proc. natn. Acad. Sci. U.S.A. 80, 2365–2369 (1983).

    Article  ADS  CAS  Google Scholar 

  19. Neurath, A. R., Kent, S. B. H. & Strick, N. Science 224, 392–394 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  20. Neurath, A. R., Kent, S. B. H., Strick, N., Taylor, P. & Stevens, C. E. Nature 315, 154–156 (1985).

    Article  ADS  CAS  PubMed  Google Scholar 

  21. Machida, A. et al. Gastroenterology 86, 910–918 (1984).

    CAS  PubMed  Google Scholar 

  22. Albin, C. & Robinson, W. S. J. Virol. 34, 297–302 (1980).

    CAS  PubMed  PubMed Central  Google Scholar 

  23. Petit, M. A. & Pillot, J. J. Virol. 53, 543–551 (1985).

    CAS  PubMed  PubMed Central  Google Scholar 

  24. Tiollais, P., Charnay, P. & Vyas, G. N. Science 213, 406–411 (1981).

    Article  ADS  CAS  PubMed  Google Scholar 

  25. Ohori, H., Shimizu, N., Yamada, E., Onodera, S. & Ishida, N. J. gen. Virol. 65, 405–414 (1984).

    Article  CAS  PubMed  Google Scholar 

  26. Takahashi, K. et al. J. Immun. 130, 2903–2907 (1983).

    CAS  PubMed  Google Scholar 

  27. Galibert, F., Mandart, E., Fitoussi, F., Tiollais, P. & Charnay, P. Nature 281, 646–650 (1979).

    Article  ADS  CAS  PubMed  Google Scholar 

  28. Pasek, M. et al. Nature 282, 575–579 (1979).

    Article  ADS  CAS  PubMed  Google Scholar 

  29. Valenzuela, P., Quiroga, M., Zaldivar, J., Gray, P. & Rutter, W.J. in Animal Viral Genetics (eds Fields, B., Jaenisch, R. & Fox, C. F.) 57–70 (Academic, New York, 1980).

    Book  Google Scholar 

  30. Ono, Y. et al. Nucleic Acids Res. 11, 1747–1757 (1983).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Fujiyama, A. et al. Nucleic Acids Res. 11, 4601–4610 (1983).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Kobayashi, M. & Koike, K. Gene 30, 227–232 (1984).

    Article  CAS  PubMed  Google Scholar 

  33. Tiollais, P. et al. in Viral Hepatitis and Liver Disease (ed. Vyas, G. N.) 49–65 (Grune & Stratton, New York, 1984).

    Google Scholar 

  34. Toh, H., Hyashida, H. & Miyata, T. Nature 305, 827–829 (1983).

    Article  ADS  CAS  PubMed  Google Scholar 

  35. Moriarty, A. M., Alexander, H. & Lerner, R. A. Science 227, 429–433 (1985).

    Article  ADS  CAS  PubMed  Google Scholar 

  36. Kay, A., Mandart, E., Trepo, C. & Galibert, G. EMBO J. 4, 1287–1292 (1985).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Galibert, F., Chen, T. N. & Mandart, E. J. Virol. 41, 51–65 (1982).

    CAS  PubMed  PubMed Central  Google Scholar 

  38. Seeger, C., Ganem, D. & Varmus, H. E. J. Virol. 51, 367–375 (1984).

    CAS  PubMed  PubMed Central  Google Scholar 

  39. Mandart, E., Kay, A. & Galibert, F. J. Virol. 49, 782–792 (1984).

    CAS  PubMed  PubMed Central  Google Scholar 

  40. Cattaneo, R., Will, H., Hernandez, N. & Schaller, H. Nature 305, 336–338 (1983).

    Article  ADS  CAS  PubMed  Google Scholar 

  41. Cattaneo, R., Will, H. & Schaller, H. EMBO J. 3, 2191–2196 (1984).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Pourcel, C. et al. J. Virol. 42, 100–105 (1982).

    CAS  PubMed  PubMed Central  Google Scholar 

  43. Gough, N. J. molec. Biol. 165, 683–699 (1983).

    Article  CAS  PubMed  Google Scholar 

  44. Rall, L. B., Standring, D. N., Laub, O. & Rutter, W. J. Molec. cell. Biol. 3, 1766–1773 (1983).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Standring, D. N., Rall, L. B., Laub, O. & Rutter, W. J. Molec. cell. Biol. 3, 1774–1782 (1983).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Möröy, T., Etiemble, J., Trépo, C., Tiollais, P. & Buendia, M. A. EMBO J. 4, 1507–1514 (1985).

    Article  PubMed  PubMed Central  Google Scholar 

  47. Büscher, M., Reiser, W., Will, H. & Schaller, H. Cell 40, 717–724 (1985).

    Article  PubMed  Google Scholar 

  48. Shaul, Y., Rutter, W. J. & Laub, O. EMBO J. 4, 427–430 (1985).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Bréechot, C. et al. Hepatology 2, 26S–34S (1982).

    Google Scholar 

  50. Shafritz, D. Hepatology 2, 35S–41S (1982).

    Google Scholar 

  51. Dejean, A., Lugassy, C., Zafrani, S., Tiollais, P. & Bréchot, C. J. gen. Virol. 65, 651–655 (1984).

    Article  PubMed  Google Scholar 

  52. Siddiqui, A. Proc. natn. Acid. Sci. U.S.A. 80, 4861–4864 (1983).

    Article  ADS  CAS  Google Scholar 

  53. Halpern, M. S. et al. Proc. natn. Acad. Sci. U.S.A. 80, 4865–4869 (1983).

    Article  ADS  CAS  Google Scholar 

  54. Romet-Lemonne, J. L. et al. Science 221, 667–669 (1983).

    Article  ADS  CAS  PubMed  Google Scholar 

  55. Pontisso, P., Poon, M. C., Tiollais, P. & Bréchot, C. B. med. J. 288, 1563–1566 (1984).

    Article  CAS  Google Scholar 

  56. Elfassi, E. et al. Proc. natn. Acad. Sci. U.S.A. 81, 3526–3528 (1984).

    Article  ADS  CAS  Google Scholar 

  57. Summers, J. & Mason, W. S. Cell 29, 403–415 (1982).

    Article  CAS  PubMed  Google Scholar 

  58. Mason, W. S., Aldrich, C., Summers, J. & Taylor, J. M. Proc. natn. Acad. Sci. U.S.A. 79, 3997–4001 (1982).

    Article  ADS  CAS  Google Scholar 

  59. Blum, H. E., Haase, A. T., Harris, J. D., Walker, D. & Vyas, G. N. Virology 139, 87–96 (1984).

    Article  CAS  PubMed  Google Scholar 

  60. Fowler, M. J. F., Monjardino, J., Tsiquaye, K. N., Zuckerman, A. J. & Thomas, H. C. J. med. Virol. 13, 83–91 (1984).,

    Article  CAS  PubMed  Google Scholar 

  61. Miller, R. H., Tran, C. T. & Robinson, W. S. Virology 139, 53–63 (1984).

    Article  CAS  PubMed  Google Scholar 

  62. Miller, R. H., Marion, P. L. & Robinson, W. S. Virology 139, 64–72 (1984).

    Article  CAS  PubMed  Google Scholar 

  63. Molnar-Kimber, K. L., Summers, J. W. & Mason, W. S. J. Virol. 51, 181–191 (1984).

    CAS  PubMed  PubMed Central  Google Scholar 

  64. Szmuness, W. Prog. med. Virol. 24, 40–69 (1978).

    CAS  PubMed  Google Scholar 

  65. Beasley, R. P., Hwang, L. Y., Lin, C. C. & Chien, C. S. Lancet vol. 2 1129–1133 (1981).

    Article  CAS  PubMed  Google Scholar 

  66. Marion, P.L., Salazar, F.H., Alexander, J.J. & Robinson, W.S. J. Virol. 33, 795–806 (1980).

    CAS  PubMed  PubMed Central  Google Scholar 

  67. Chakraborty, P. R., Ruiz-Opazo, N., Shouval, D. & Shafritz, D. A. Nature 286, 531–533 (1980).

    Article  ADS  CAS  PubMed  Google Scholar 

  68. Bréchot, C., Pourcel, C., Louise, A., Rain, B. & Tiollais, P. Nature 286, 533–535 (1980).

    Article  ADS  PubMed  Google Scholar 

  69. Edman, J. C., Gray, P., Valenzuela, P., Rall, L. B. & Rutter, W. J. Nature 286, 535–538 (1980).

    Article  ADS  CAS  PubMed  Google Scholar 

  70. Chen, D. S., Hoyer, B. H., Nelson, J., Purcell, R. H. & Gerin, J. L. Hepatology 2, 42S–45S (1982).

    Google Scholar 

  71. Shafritz, D. A., Shouval, D., Sherman, H. I., Hadziyannis, S. J. & Kew, M. C. New Engl. J. Med. 305, 1067–1073 (1981).

    Article  CAS  PubMed  Google Scholar 

  72. Hino, O. et al. Hepatology 4, 90–95 (1984).

    Article  CAS  PubMed  Google Scholar 

  73. Hirohashi, S., Shimosato, Y., Ino, Y. & Kishi, K. J. natn. Cancer Inst. 69, 565–568 (1982).

    CAS  Google Scholar 

  74. Eddelston, A. L. W. F., Mondelli, M., Mieli-Vergani, G. & Williams, R. Hepatology 2, 112S–127S (1982).

    Google Scholar 

  75. Bréchot, C. et al. New Engl. J. Med. 306, 1384–1387 (1982).

    Article  PubMed  Google Scholar 

  76. Figus, A. et al. Hepatology 4, 364–368 (1984).

    Article  CAS  PubMed  Google Scholar 

  77. Hino, O., Kitagawa, T. & Sugano, H. Int. J. Cancer 35, 5–10 (1985).

    Article  CAS  PubMed  Google Scholar 

  78. Bréchot, C. et al. New Engl. J. Med. 312, 270–276 (1985).

    Article  PubMed  Google Scholar 

  79. Bréchot, C. et al. Lancet ii, 765–768 (1981).

    Article  Google Scholar 

  80. Dejean, A., Brechot, C., Tiollais, P. & Wain-Hobson, S. Proc. natn. Acad. Sci. U.S.A. 80, 2505–2509 (1983).

    Article  ADS  CAS  Google Scholar 

  81. Dejean, A., Sonigo, P., Wain-Hobson, S. & Tiollais, P. Proc. natn. Acad. Sci. U.S.A. 81, 5350–5354 (1984).

    Article  ADS  CAS  Google Scholar 

  82. Koshy, R. et al. Cell 34, 215–223 (1983).

    Article  CAS  PubMed  Google Scholar 

  83. Shaul, Y. et al. J. Virol. 51, 776–787 (1984).

    CAS  PubMed  PubMed Central  Google Scholar 

  84. Mizusawa, H. et al. Proc. natn. Acad. Sci. U.S.A. 82, 208–212 (1985).

    Article  ADS  CAS  Google Scholar 

  85. Ziemer, M., Garcia, P., Shaul, Y. & Rutter, W. J. J. Virol. 53, 885–892 (1985).

    CAS  PubMed  PubMed Central  Google Scholar 

  86. Botchan, M., Topp, W. & Sambrook, J. Cell 9, 269–287 (1976).

    Article  CAS  PubMed  Google Scholar 

  87. Sambrook, J. et al. Cold Spring Harb. Symp. quant. Biol. 44, 569–584 (1980).

    Article  CAS  PubMed  Google Scholar 

  88. Ogston, C. W., Jonak, G. J., Rogler, C. E., Astrin, S. M. & Summers, J. Cell 29, 385–394 (1982).

    Article  CAS  PubMed  Google Scholar 

  89. Freytag von Loringhoven, A., Koch, S., Hofschneider, P. H. & Koshy, R. EMBO J. 4, 249–255 (1985).

    Article  Google Scholar 

  90. Crosnier, J. et al. Lancet i, 455–459 (1981).

    Article  Google Scholar 

  91. Laplanche, A. et al. Lancet i, 222 (1982).

    Article  Google Scholar 

  92. Szmuness, W. et al. New Engl. J. Med. 307, 1481–1486 (1982).

    Article  CAS  PubMed  Google Scholar 

  93. Maupas, P. et al. Lancet i, 289–292 (1981).

    Article  Google Scholar 

  94. Lee, G. C. Y. et al. J. infect. Dis. 148, 526–529 (1983).

    Article  CAS  PubMed  Google Scholar 

  95. Prozesky, O. W. et al. J. infect. Dis., 7 Suppl. 1, 53–57 (1983).

    Google Scholar 

  96. Skelly, J., Howard, C. R. & Zuckerman, A. J. Nature 290, 51–54 (1981).

    Article  ADS  CAS  PubMed  Google Scholar 

  97. Cohen, B. J. & Richemond, J. E. Nature 296, 677–678 (1982).

    Article  ADS  CAS  PubMed  Google Scholar 

  98. Charnay, P., Gervais, M., Louise, A., Galibert, F. & Tiollais, P. Nature 286, 893–895 (1980).

    Article  ADS  CAS  PubMed  Google Scholar 

  99. Edman, J. C., Hallewell, R. A., Valenzuela, P., Goodman, H. M. & Rutter, W. J. Nature 291, 503–506 (1981).

    Article  ADS  CAS  PubMed  Google Scholar 

  100. Fujisawa, Y. et al. Nucleic Acids Res. 11, 3581–3590 (1983).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  101. Dubois, M. F. et al. Proc. natn. Acad. Sci. U.S.A. 77, 4549–4553 (1980).

    Article  ADS  CAS  Google Scholar 

  102. Valenzuela, P., Medina, A., Rutter, W. J., Ammerer, G. & Hall, B. D. Nature 298, 347–350 (1982).

    Article  ADS  CAS  PubMed  Google Scholar 

  103. Miyanohara, A. Proc. natn. Acad. Sci. U.S.A. 80, 1–5 (1983).

    Article  ADS  CAS  Google Scholar 

  104. McAleer, W. J. et al. Nature 307, 178–180 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  105. Michel, M. L. et al. Proc. natn. Acad. Sci. U.S.A. 81, 7708–7712 (1984).

    Article  ADS  CAS  Google Scholar 

  106. Patzer, E. J. et al. in Viral Hepatitis and Liver Disease (ed. Vyas, G. N.) 477–485 (Grune & Stratton, New York, 1984).

    Google Scholar 

  107. Milich, D. R. et al. Science 228, 1195–1199 (1985).

    Article  ADS  CAS  PubMed  Google Scholar 

  108. Smith, G. L., Mackett, M. & Moss, B. Nature 302, 490–495 (1983).

    Article  ADS  CAS  PubMed  Google Scholar 

  109. Moss, B., Smith, G. L., Gerin, J. L. & Purcell, R. H. Nature 311, 67–69 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  110. Enders, G. H., Ganem, D. & Varmus, H. Cell (in the press).

  111. Blumberg, B. S., Alter, H. J. & Visnich, S. J. Am. med. Ass. 191, 541–546 (1965).

    Article  CAS  Google Scholar 

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  1. Unité de Recombinaison et Expression Génétique, INSERM U163, CNRS LA 271, Institut Pasteur, 28 rue du Dr Roux, 75015, Paris, France

    Pierre Tiollais, Christine Pourcel & Anne Dejean

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  1. Pierre Tiollais
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  2. Christine Pourcel
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Tiollais, P., Pourcel, C. & Dejean, A. The hepatitis B virus. Nature 317, 489–495 (1985). https://doi.org/10.1038/317489a0

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