Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Structure of a human common cold virus and functional relationship to other picornaviruses

Nature volume 317, pages 145–153 (1985)Cite this article

Abstract

We report the first atomic resolution structure of an animal virus, human rhinovirus 14. It is strikingly similar to known icosahedral plant RNA viruses. Four neutralizing immunogenic regions have been identified. These, and corresponding antigenic sequences of polio and foot-and-mouth disease viruses, reside on external protrusions. A large cleft on each icosahedral face is probably the host cell receptor binding site.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Rueckert, R. R. Comprehensive Virology Vol. 6 (eds Fraenkel-Conrat, H. & Wagner, R. R.) 131–213 (Plenum, New York, 1976).

    Google Scholar 

  2. Rueckert, R. R. & Wimmer, E. J. Virol. 50, 957–959 (1984).

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Jacobson, M. F., Asso, J. & Baltimore, D. J. molec. Biol. 49, 657–669 (1970).

    Article  CAS  PubMed  Google Scholar 

  4. Pallansch, M. A. et al. J. Virol. 49, 873–880 (1984).

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Hanecak, R., Semler, B. L., Anderson, C. W. & Wimmer, E. Proc. natn. Acad. Sci. U.S.A. 79, 3973–3977 (1982).

    Article  ADS  CAS  Google Scholar 

  6. Lonberg-Holm, K. & Butterworth, B. E. Virology, 71, 207–216 (1976).

    Article  CAS  PubMed  Google Scholar 

  7. Beneke, T. W., Habermehl, K. O., Diefenthal, W. & Buchholz, M. J. gen. Virol. 34, 387–390 (1977).

    Article  CAS  PubMed  Google Scholar 

  8. Hordern, J. S., Leonard, J. D. & Scraba, D. G. Virology, 97, 131–140 (1979).

    Article  CAS  PubMed  Google Scholar 

  9. Wetz, K. & Habermehl, K. O. J. gen. Virol. 59, 387–401 (1982).

    Article  Google Scholar 

  10. Stanway, G., Hughes, P. J., Mountford, R. C., Minor, P. D. & Almond, J. W. Nucleic Acids Res. 12, 7859–7875 (1984).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Callahan, P. L., Mizutani, S. & Colonno, R. J. Proc. natn. Acad. Sci. U.S.A. 82, 732–736 (1985).

    Article  ADS  CAS  Google Scholar 

  12. Skern, T. et al. Nucleic Acids Res. 13, 2111–2126 (1985).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Finch, J. T. & Klug, A. Nature 183, 1709–1714 (1959).

    Article  ADS  CAS  PubMed  Google Scholar 

  14. Harrison, S. C., Olson, A. J., Schutt, C. E., Winkler, F. K. & Bricogne, G. Nature 276, 368–373 (1978).

    Article  ADS  CAS  PubMed  Google Scholar 

  15. Abad-Zapatero, C. et al. Nature 286, 33–39 (1980).

    Article  ADS  CAS  PubMed  Google Scholar 

  16. Liljas, L. et al. J. molec. Biol. 159, 93–108 (1982).

    Article  CAS  PubMed  Google Scholar 

  17. Hogle, J. M. J. molec. Biol. 160, 663–668 (1982).

    Article  CAS  PubMed  Google Scholar 

  18. Arnold, E. et al. J. molec. Biol. 177, 417–430 (1984).

    Article  CAS  PubMed  Google Scholar 

  19. Rossmann, M. G. & Blow, D. M. Acta crystallogr. 15, 24–31 (1962).

    Article  CAS  Google Scholar 

  20. Argos, P., Ford, G. C. & Rossmann, M. G. Acta crystallogr. A31, 499–506 (1975).

    Article  Google Scholar 

  21. Bricogne, G. Acta crystallogr. A32, 832–847 (1976).

    Article  Google Scholar 

  22. Jones, T. A. J. appl. Crystalllogr. 11, 268–272 (1978).

    Article  CAS  Google Scholar 

  23. Rossmann, M. G. & Blow, D. M. Acta crystallogr. 16, 39–45 (1963).

    Article  CAS  Google Scholar 

  24. Caspar, D. L. D. & Klug, A. Cold Spring Harb. Symp. quant. Biol. 27, 1–24 (1962).

    Article  CAS  PubMed  Google Scholar 

  25. Sherry, B. & Rueckert, R. J. Virol. 53, 137–143 (1985).

    CAS  PubMed  PubMed Central  Google Scholar 

  26. Pfaff, E., Mussgay, M., Böhm, H. O., Schulz, G. E. & Schaller, H. EMBO J. 1, 869–874 (1982).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Icenogle, J. et al. Virology 127, 412–425 (1983).

    Article  CAS  PubMed  Google Scholar 

  28. Mandel, B. Virology 69, 500–510 (1976),

    Article  CAS  PubMed  Google Scholar 

  29. Emini, E. A., Jameson, B. A. & Wimmer, E. Nature 304, 699–703 (1983).

    Article  ADS  CAS  PubMed  Google Scholar 

  30. Emini, E. A., Ostapchuk, P. & Wimmer, E. J. Virol. 48, 547–550 (1983).

    CAS  PubMed  PubMed Central  Google Scholar 

  31. Sherry, B., Mosser, A. G., Colonno, R. J. & Rueckert, R. R. J. Virol. (in the press).

  32. Meloen, R. H., Briaire, J., Woortmeyer, R. J. & Van Zaane, D. J. gen. Virol. 64, 1193–1198 (1983).

    Article  CAS  PubMed  Google Scholar 

  33. Abraham, G. & Colonno, R. J. J. Virol. 51, 340–345 (1984).

    CAS  PubMed  PubMed Central  Google Scholar 

  34. Krah, D. L. & Crowell, R. L. J. Virol. 53, 867–870 (1985).

    CAS  PubMed  PubMed Central  Google Scholar 

  35. Lonberg-Holm, K. J. gen. Virol. 28, 313–327 (1975).

    Article  CAS  PubMed  Google Scholar 

  36. Cavanagh, D., Sangar, D. V., Rowlands, D. J. & Brown, F. J. gen. Virol. 35, 149–158 (1977).

    Article  CAS  PubMed  Google Scholar 

  37. Strohmaier, K., Franze, R. & Adam, K. H. J. gen. Virol. 59, 295–306 (1982).

    Article  CAS  PubMed  Google Scholar 

  38. Baxt, B., Morgan, D. O., Robertson, B. H. & Timpone, C. A. J. Virol. 51, 298–305 (1984).

    CAS  PubMed  PubMed Central  Google Scholar 

  39. Argos, P., Tsukihara, T. & Rossmann, M. G. J. molec. Evol. 15, 169–179 (1980).

    Article  ADS  CAS  PubMed  Google Scholar 

  40. Rossmann, M. G., Abad- Zapatero, C., Hermodson, M. A. & Erickson, J. W. J. molec. Biol. 166, 37–83 (1983).

    Article  CAS  PubMed  Google Scholar 

  41. Erickson, J. W., Silva, A. M., Murthy, M. R. N., Fita, I. & Rossmann, M. G. Science 229, 625–629 (1985).

    Article  ADS  CAS  PubMed  Google Scholar 

  42. Rossmann, M. G. & Argos, P. A. Rev. Biochem. 60, 497–532 (1981).

    Article  Google Scholar 

  43. Franssen, H., Leunissen, J., Goldbach, R., Lomonossoff, G. & Zimmern, D. EMBO J. 3, 855–861 (1984).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Argos, P., Kamer, G., Nicklin, M. J. H. & Wimmer, E. Nucleic Acids Res. 12, 7251–7267 (1984).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Haseloff, J. et al. Proc. natn. Acad. Sci. U.S.A. 81, 4358–4362 (1984).

    Article  ADS  CAS  Google Scholar 

  46. Chow, M., Yabrov, R., Bittle, J., Hogle, J. & Baltimore, D. Proc. natn. Acad. Sci. U.S.A. 82, 910–914 (1985).

    Article  ADS  CAS  Google Scholar 

  47. Wychowski, C. et al. EMBO J. 2, 201–2024 (1983).

    Article  Google Scholar 

  48. Evans, D. M. A., Minor, P. D., Schild, G. S. & Almond, J. W. Nature 304, 459–462 (1983).

    Article  ADS  CAS  PubMed  Google Scholar 

  49. Minor, P. D. et al. Nature 301, 674–679 (1983).

    Article  ADS  CAS  PubMed  Google Scholar 

  50. van der Werf, S. et al. Proc. natn. Acad. Sci. U.S.A. 80, 5080–5084 (1983).

    Article  ADS  CAS  Google Scholar 

  51. Bittle, J. L. et al. Nature 298, 30–33 (1982).

    Article  ADS  CAS  PubMed  Google Scholar 

  52. Robertson, B. H., Morgan, D. O. & Moore, D. M. Virus Res. 1, 489–500 (1984).

    Article  CAS  PubMed  Google Scholar 

  53. Emini, E. A., Jameson, B. A. & Wimmer, E. in Modern Approaches to Vaccines (eds Chanock, R. M. & Lerner, R. A.) 65–75 (Cold Spring Harbor Laboratory, New York, 1984).

    Google Scholar 

Download references

Author information

Author notes

  1. John W. Erickson

    Present address: Department of Physical Biochemistry, AP-9A D-47E, Abbott Laboratories, Abbott Park, North Chicago, Illinois, 60064, USA

  2. Elizabeth A. Frankenberger

    Present address: Department of Agronomy, Purdue University, West Lafayette, Indiana, 47907, USA

  3. Hans-Jürgen Hecht

    Present address: F. G. Roentgenstrukturanalyse, Universitaet Wuerzburg, Zentralbau Chemie, Am Hubland, D-8700, Wuerzburg, FRG

Authors and Affiliations

  1. Department of Biological Sciences, Purdue University, West Lafayette, Indiana, 47907, USA

    Michael G. Rossmann, Edward Arnold, John W. Erickson, Elizabeth A. Frankenberger, James P. Griffith, Hans-Jürgen Hecht, John E. Johnson, Greg Kamer, Ming Luo & Gerrit Vriend

  2. Biophysics Lab, University of Wisconsin, 1525 Linden Drive, Madison, Wisconsin, 53706, USA

    Anne G. Mosser, Roland R. Rueckert & Barbara Sherry

Authors
  1. Michael G. Rossmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Edward Arnold
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. John W. Erickson
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Elizabeth A. Frankenberger
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. James P. Griffith
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hans-Jürgen Hecht
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. John E. Johnson
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Greg Kamer
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Ming Luo
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Anne G. Mosser
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Roland R. Rueckert
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Barbara Sherry
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Gerrit Vriend
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rossmann, M., Arnold, E., Erickson, J. et al. Structure of a human common cold virus and functional relationship to other picornaviruses. Nature 317, 145–153 (1985). https://doi.org/10.1038/317145a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/317145a0

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing