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Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

Nature volume 311, pages 433–438 (1984)Cite this article

Abstract

Transcription of the c-fos proto-oncogene is greatly increased within minutes of administering purified growth factors to quiescent 3T3 cells. This stimulation is the most rapid transcriptional response to peptide growth factors yet described, and implies a role for c-fos in cell-cycle control Transformation by c-fos may result from a temporal deregulation of this control.

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References

  1. Pardee, A. B., Dubrow, R., Hamlin, J. L. & Kletzien, R. F. A. Rev. Biochem. 47, 715–750 (1978).

    CAS  Google Scholar 

  2. Stiles, C. D. Cell 33, 653–655 (1983).

    CAS  PubMed  Google Scholar 

  3. Bishop, J. M. & Varmus, H. E. in RNA Tumour Viruses, Molecular Biology of Tumour Viruses (eds Weiss, R., Teich, N., Varmus, H. E. & Coffin, J.) 999–1108 (Cold Spring Harbor Laboratory, New York,. 1982).

    Google Scholar 

  4. Waterfield, M. D. et al. Nature 304, 35–39 (1983).

    ADS  CAS  PubMed  Google Scholar 

  5. Doolittle, R. F. et al. Science 221, 275–277 (1983).

    ADS  CAS  PubMed  Google Scholar 

  6. Downward, J. et al. Nature 307, 521–527 (1984).

    ADS  CAS  PubMed  Google Scholar 

  7. Ek, B., Westermark, B., Wasteson, A. & Heldin, C.-H. Nature 295, 419–420 (1982).

    ADS  CAS  PubMed  Google Scholar 

  8. Nishimura, J., Huang, J. S. & Deuel, T. F. Proc. natn. Acad. Sci. U.S.A. 79, 4303–4307 (1982).

    ADS  CAS  Google Scholar 

  9. Cooper, J. A., Bowen-Pope, D. F., Raines, E., Ross, R. & Hunter, T. Cell 31, 263–273 (1982).

    CAS  PubMed  Google Scholar 

  10. Ushiro, H. & Cohen, S. J. biol. Chem. 255, 8363–8365 (1980).

    CAS  PubMed  Google Scholar 

  11. Hunter, T. & Cooper, J. A. Cell 24, 741–752 (1981).

    CAS  PubMed  Google Scholar 

  12. Kasuga, M., Zick, Y., Blithe, D. L., Crettaz, M. & Kahn, C. R. Nature 298, 667–669 (1982).

    ADS  CAS  PubMed  Google Scholar 

  13. Petruzzelli, L. M. et al. Proc. natn. Acad. Sci. U.S.A. 79, 6792–6796 (1982).

    ADS  CAS  Google Scholar 

  14. Todaro, G. J., Lazar, G. K. & Green, H. J. cell. comp. Physiol. 66, 325–334 (1965).

    CAS  Google Scholar 

  15. Antoniades, H. N., Scher, C. D. & Stiles, C. D. Proc. natn. Acad. Sci. U.S.A. 76, 1809–1813 (1979).

    ADS  CAS  Google Scholar 

  16. Deuel, T. F. et al. J. biol. Chem. 256, 8896–8899 (1981).

    CAS  PubMed  Google Scholar 

  17. Heldin, C. H., Westermark, B. & Wasteson, A. Proc. natn. Acad. Sci. U.S.A. 76, 3722–3726 (1979).

    ADS  CAS  Google Scholar 

  18. Raines, E. W. & Ross, R. J. biol. Chem. 257, 5154–5160 (1982).

    CAS  PubMed  Google Scholar 

  19. Pledger, W. J., Stiles, C. D., Antoniades, H. N. & Scher, C. D. Proc. natn. Acad. Sci. U.S.A. 74, 4481–4485 (1977).

    ADS  CAS  Google Scholar 

  20. Stiles, C. D. et al. Proc. natn. Acad. Sci. U.S.A. 76, 1279–1283 (1979).

    ADS  CAS  Google Scholar 

  21. Scher, C. D., Hendrickson, S. L., Whipple, A. P., Gottesman, M. M. & Pledger, W. J. Cold Spring Harb. Conf. Cell Proliferation 9, 289–303 (1982).

    CAS  Google Scholar 

  22. Vogel, A., Raines, E., Kariya, A., Rivest, M.-J. & Ross, R. Proc. natn. Acad. Sci. U.S.A. 75, 2810–2814 (1978).

    ADS  CAS  Google Scholar 

  23. Singh, J. P., Chaikin, M. A., Pledger, W. J., Scher, C. D. & Stiles, C. D. J. Cell Biol. 96, 1497–1502 (1983).

    CAS  PubMed  Google Scholar 

  24. Glenn, K., Bowen-Pope, D. F. & Ross, R. J. biol. Chem. 257, 5172–5176 (1982).

    CAS  PubMed  Google Scholar 

  25. Frackelton, A. R., Tremble, P. M. & Williams, L. T. J. biol. Chem. 259, 7909–7915 (1984).

    CAS  PubMed  Google Scholar 

  26. Kelly, K., Cochran, B. H., Stiles, C. D. & Leder, P. Cell 35, 603–610 (1983).

    CAS  PubMed  Google Scholar 

  27. Campisi, J., Gray, H. E., Pardee, A. B., Dean, M. & Sonenshein, G. E. Cell 36, 241–247 (1984).

    CAS  PubMed  Google Scholar 

  28. Hann, S. R., Abrams, H. D., Rohrschneider, L. R. & Eisenman, R. N. Cell 34, 789–798 (1983).

    CAS  PubMed  Google Scholar 

  29. Hayward, W. S., Neel, B. G. & Astrin, S. M. Nature 290, 475–480 (1981).

    Article  ADS  CAS  PubMed  Google Scholar 

  30. Collins, S. & Groudine, M. Nature 298, 679–681 (1982).

    ADS  CAS  PubMed  Google Scholar 

  31. Dalla-Favera, R., Wong-Staal, F. & Gallo, R. C. Nature 299, 61–63 (1982).

    ADS  CAS  PubMed  Google Scholar 

  32. Alitalo, K. et al. Proc. natn. Acad. Sci. U.S.A. 80, 100–104 (1983).

    ADS  CAS  Google Scholar 

  33. Taub, R. et al. Proc. natn. Acad. Sci. U.S.A. 78, 7837–7841 (1982).

    ADS  Google Scholar 

  34. Dalla-Favera, R. et al. Proc. natn. Acad. Sci. U.S.A. 79, 7824–7827 (1982).

    ADS  CAS  Google Scholar 

  35. Marcu, K. B. et al. Proc. natn. Acad. Sci. U.S.A. 80, 519–523 (1983).

    ADS  CAS  Google Scholar 

  36. Shen-Ong, G. L. C., Keath, E. J., Piccoli, S. P. & Cole, M. D. Cell 31, 443–452 (1982).

    CAS  PubMed  Google Scholar 

  37. Slamon, D. J., de Kernion, J. B., Verma, I. M. & Cline, M. J. Science 224, 256–262 (1984).

    ADS  CAS  PubMed  Google Scholar 

  38. McKnight, G. S. & Palmiter, R. J. biol. Chem. 254, 9050–9058 (1979).

    CAS  PubMed  Google Scholar 

  39. Groudine, M., Peretz, M. & Weintraub, H. Molec. cell. Biol. 1, 281–288 (1981).

    CAS  PubMed  PubMed Central  Google Scholar 

  40. Finkel, M. P., Biskis, B. O. & Jinkins, P. B. Science 151, 698–701 (1966).

    ADS  CAS  PubMed  Google Scholar 

  41. Curran, T., MacConnell, W. P., van Straaten, F. & Verma, I. M. Molec. cell. Biol. 3, 914–921 (1983).

    CAS  PubMed  PubMed Central  Google Scholar 

  42. Van Beveren, C., van Straaten, F., Curran, T., Muller, R. & Verma, I. M. Cell 32, 1241–1255 (1983).

    CAS  PubMed  Google Scholar 

  43. Curran, T., Miller, D. A., Zokas, L. & Verma, I. M. Cell 36, 259–268 (1984).

    CAS  PubMed  Google Scholar 

  44. Muller, R., Slamon, D. J. Tremblay, J. M., Cline, M. J. & Verma, I. M. Nature 299, 640–644 (1982).

    ADS  CAS  PubMed  Google Scholar 

  45. Muller, R., Verma, I. M. & Adamson, E. D. EMBO J. 2, 679–684 (1983).

    CAS  PubMed  PubMed Central  Google Scholar 

  46. Clayton, D. F. & Darnell, J. E. Molec. cell. Biol. 3, 1552–1561 (1983).

    CAS  PubMed  PubMed Central  Google Scholar 

  47. Delisle, A. J., Graves, R. A., Marzluff, W. F. & Johnson, L. F. Molec. cell. Biol. 3, 1920–1929 (1983).

    CAS  PubMed  PubMed Central  Google Scholar 

  48. Alterman, R.-B. M. et al. Molec. cell. Biol. 4, 123–132 (1984).

    CAS  PubMed  PubMed Central  Google Scholar 

  49. Stein, G. S. et al. Cold Spring Harb. Symp. quant. Biol. 42, 1107–1119 (1977).

    Google Scholar 

  50. Leys, E. J., Crouse, G. F. & Kellems, R. E. J. Cell Biol. 99, 180–187 (1984).

    CAS  PubMed  Google Scholar 

  51. Marzluff, W. F. Meth. Cell Biol. 19, 317–331 (1978).

    Google Scholar 

  52. Riddle, V. G. H., Dubrow, R. & Pardee, A. B. Proc. natn. Acad. Sci. U.S.A. 76, 1298–1302 (1979).

    ADS  CAS  Google Scholar 

  53. Cleveland, D. W. et al. Cell 20, 95–105 (1980).

    CAS  PubMed  Google Scholar 

  54. Gunning, P. et al. Molec. cell. Biol. 3, 787–795 (1983).

    CAS  PubMed  PubMed Central  Google Scholar 

  55. Klempnauer, K.-H., Symonds, G., Evan, G. I. & Bishop, J. M. Cell 37, 537–547 (1984).

    CAS  PubMed  Google Scholar 

  56. Scolnick, E. M., Papageorge, A. G. & Shih, T. Y. Proc. natn. Acad. Sci. U.S.A. 76, 5355–5359 (1979).

    ADS  CAS  Google Scholar 

  57. Willingham, M. C., Pastan, I., Shih, T. Y. & Scolnick, E. M. Cell 19, 1005–1014 (1980).

    CAS  PubMed  Google Scholar 

  58. Wang, J. Y. J., Ledley, F., Goff, S., Lee, R., Groner, Y. & Baltimore, B. Cell 36, 349–356 (1984).

    CAS  PubMed  Google Scholar 

  59. Naharro, G. et al. J. Virol. 47, 611–619 (1983).

    CAS  PubMed  PubMed Central  Google Scholar 

  60. Naharro, G., Robbins, K. C. & Reddy, E. P. Science 223, 63–66 (1984).

    ADS  CAS  PubMed  Google Scholar 

  61. Curran, T., Peters, G., Van Beveren, C., Teich, N. M. & Verma, I. M. J. Virol. 44, 674–682 (1982).

    CAS  PubMed  PubMed Central  Google Scholar 

  62. Stanton, L. W., Watt, R. & Marcu, K. B. Nature 303, 401–406 (1983).

    ADS  CAS  PubMed  Google Scholar 

  63. Frantz, C. N., Stiles, C. D. & Scher, C. D. J. cell. Physiol. 100, 413–424 (1979).

    CAS  PubMed  Google Scholar 

  64. Ringold, G. M., Yamamoto, K. R., Bishop, J. M. & Varmus, H. E. Proc. natn. Acad. Sci. U.S.A. 74, 2879–2883 (1977).

    ADS  CAS  Google Scholar 

  65. Miller, A. D., Curran, T. & Verma, I. M. Cell 36, 51–60 (1984).

    CAS  PubMed  Google Scholar 

  66. Castagna, M. et al. J. biol. Chem. 257, 7847–7851 (1982).

    CAS  PubMed  Google Scholar 

  67. Yamanishi, J. et al. Biochem. biophys. Res. Commun. 112, 778–786 (1983).

    CAS  PubMed  Google Scholar 

  68. Bishop, R., Martinez, R., Nakamura, K. D. & Weber, M. J. Biochem. biophys. Res. Commun. 115, 536–543 (1983).

    CAS  PubMed  Google Scholar 

  69. Gilmore, T. & Martin, G. S. Nature 306, 407–490 (1983).

    Google Scholar 

  70. Cooper, J. A., Sefton, B. M. & Hunter, T. Molec. Cell. Biol. 4, 30–37 (1984).

    CAS  PubMed  PubMed Central  Google Scholar 

  71. Cochran, B. H., Reffel, A. C. & Stiles, C. D. Cell 33, 939–947 (1983).

    CAS  PubMed  Google Scholar 

  72. Goff, S. P., Gilboa, E., Witte, O. N. & Baltimore, D. Cell 22, 777–785 (1980).

    CAS  PubMed  Google Scholar 

  73. Klempnauer, K.-H., Gonda, T. J. & Bishop, J. M. Cell 31, 453–463 (1982).

    CAS  PubMed  Google Scholar 

  74. Vennstrom, B. & Bishop, J. M. Cell 28, 135–143 (1982).

    CAS  PubMed  Google Scholar 

  75. DeLorbe, W. J., Luciw, P. A., Goodman, H. M., Varmus, H. E. & Bishop, J. M. J. Virol. 36, 50–61 (1980).

    CAS  PubMed  PubMed Central  Google Scholar 

  76. Ellis, R. W. et al. Nature 292, 506–511 (1981).

    ADS  CAS  PubMed  Google Scholar 

  77. Shibuya, M. & Hanafusa, H. Cell 30, 787–795 (1982).

    CAS  PubMed  Google Scholar 

  78. Oskarsson, M., McClements, W. L., Blair, D. G., Maizel, J. V. & Vande Woude, G. F. Science 207, 1222–1224 (1980).

    ADS  CAS  PubMed  Google Scholar 

  79. Wilhelmsen, K. C. & Temin, H. M. J. Virol. 49, 521–529 (1984).

    CAS  PubMed  PubMed Central  Google Scholar 

  80. Naharro, G. et al. J. Virol. 47, 611 (1983).

    CAS  PubMed  PubMed Central  Google Scholar 

  81. Neckameyer, W. S. & Wang, L.-H. J. Virol. 50, 914–921 (1984).

    CAS  PubMed  PubMed Central  Google Scholar 

  82. Rapp, U. R. et al. Proc. natn. Acad. Sci. U.S.A. 80, 4218–4222 (1983).

    ADS  CAS  Google Scholar 

  83. Donner, L., Fedele, L. A., Garon, C. F., Andersen, S. J. & Sherr, C. J. J. Virol. 41, 489–500 (1982).

    CAS  PubMed  PubMed Central  Google Scholar 

  84. Andersen, P. R., Tronick, S. R. & Aaronson, S. A. J. Virol. 40, 431–439 (1981).

    CAS  PubMed  PubMed Central  Google Scholar 

  85. Kitamura, N., Kitamura, A., Toyoshima, K., Hirayama, Y. & Yoshida, M. Nature 297, 205–208 (1982).

    ADS  CAS  PubMed  Google Scholar 

  86. Oren, M. & Levine, A. J. Proc. natn. Acad. Sci. U.S.A. 80, 56–59 (1983).

    ADS  CAS  Google Scholar 

  87. Chang, A. C. Y. et al. Nature 275, 617–624 (1978).

    ADS  CAS  PubMed  Google Scholar 

  88. Zhong, R., Roeder, R. G. & Heintz, N. Nucleic Acids Res. 11, 7409–7425 (1983).

    CAS  PubMed  PubMed Central  Google Scholar 

  89. Edelman, G. M. and Chuong, C.-M. Proc. natn. Acad. Sci. U.S.A. 79, 7036–7040 (1982).

    ADS  CAS  Google Scholar 

  90. Frazer, N. W. & Ziff, E. J. molec. Biol. 124, 27–51 (1978).

    Google Scholar 

  91. Cheng-Kiang, S., Wolgemuth, D. J., Hsu, M.-T. & Darnell, J. E. Cell 28, 575–584 (1982).

    Google Scholar 

  92. Rigby, P. W. J., Dieckmann, M., Rhodes, C. & Berg, P. J. molec. Biol. 113, 237–251 (1977).

    CAS  PubMed  Google Scholar 

  93. Lopes-Rivas, A., Stroobant, P., Waterfield, M. D. & Rozengurt, E. EMBO J. 3, 939–944 (1984).

    Google Scholar 

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  1. Kaplan Cancer Center and Department of Biochemistry, New York University Medical Center, 550 First Avenue, New York, New York, 10016, USA

    Michael E. Greenberg & Edward B. Ziff

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Greenberg, M., Ziff, E. Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. Nature 311, 433–438 (1984). https://doi.org/10.1038/311433a0

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