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Localization of the c-abl oncogene adjacent to a translocation break point in chronic myelocytic leukaemia

Nature volume 306, pages 239–242 (1983)Cite this article

Abstract

The human c-abl oncogene maps within the region (q34-qter) of chromosome 9 which is translocated to chromosome 22, the Philadelphia (Ph′) chromosome, in chronic myelocytic leukaemia (CML). The position of the Ph′ chromosomal break point is shown to be variable and, in one CML patient, has been localized immediately 5′ of, or within, the c-abl oncogene. A DNA restriction fragment corresponding to this site has been molecularly cloned and shown to represent a chimaeric fragment of DNA from chromosomes 9 and 22.

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Authors and Affiliations

  1. Laboratory of Viral Carcinogenesis, National Cancer Institute-FCRF, Frederick, Maryland, 21701, USA

    Nora Heisterkamp, John R. Stephenson & John Groffen

  2. Carcinogenesis Intramural Program, Frederick Cancer Research Facility, Frederick, Maryland, 21701, USA

    Pamela F. Hansen

  3. Department of Cell Biology and Genetics, Erasmus University, PO Box 1738, Rotterdam, 3000 DR, The Netherlands

    Annelies de Klein, Claus R. Bartram & Gerard Grosveld

Authors
  1. Nora Heisterkamp
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  2. John R. Stephenson
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  3. John Groffen
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  4. Pamela F. Hansen
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  5. Annelies de Klein
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  6. Claus R. Bartram
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  7. Gerard Grosveld
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Heisterkamp, N., Stephenson, J., Groffen, J. et al. Localization of the c-abl oncogene adjacent to a translocation break point in chronic myelocytic leukaemia. Nature 306, 239–242 (1983). https://doi.org/10.1038/306239a0

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