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Tumorigenicity of cells transformed by adenovirus type 12 by evasion of T-cell immunity

Nature volume 305, pages 776–779 (1983)Cite this article

Abstract

Evidence is presented that cells transformed by adenovirus type 12 are oncogenic because they escape from T-cell immunity. This effect is brought about by reducing the expression of class I transplantation antigens and is a function of the protein translated from the 13S mRNA, transcribed from early region 1a. These findings establish a novel mechanism by which transformed cells can acquire an oncogenic phenotype.

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Authors and Affiliations

  1. Department of Medical Biochemistry, Sylvius Laboratories, State University, Wassenaarseweg 72, Leiden, 2333 AL, The Netherlands

    R. Bernards, P. I. Schrier, A. Houweling, J. L. Bos & A. J. van der Eb

  2. Department of Tumor Immunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, PO Box 9190, Amsterdam, The Netherlands

    M. Zijlstra & C. J. M. Melief

Authors
  1. R. Bernards
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  2. P. I. Schrier
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  3. A. Houweling
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  4. J. L. Bos
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  5. A. J. van der Eb
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  6. M. Zijlstra
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  7. C. J. M. Melief
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Bernards, R., Schrier, P., Houweling, A. et al. Tumorigenicity of cells transformed by adenovirus type 12 by evasion of T-cell immunity. Nature 305, 776–779 (1983). https://doi.org/10.1038/305776a0

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