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Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus

Nature volume 297, pages 479–483 (1982)Cite this article

Abstract

A normal human gene homologous to the p21 ras oncogene of Harvey murine sarcoma virus induced oncogenic transformation and high p21 ras levels in murine fibroblasts when this gene was ligated to a control element (the long terminal repeat) from a murine or feline retrovirus. These results indicate that high levels of a gene product encoded by a normal human oncogene can induce tumorigenic transformation.

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Author notes

  1. Esther H. Chang

    Present address: Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, 20014, USA

Authors and Affiliations

  1. Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20205, USA

    Esther H. Chang & Douglas R. Lowy

  2. Laboratory of Tumor Virus Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20205, USA

    Mark E. Furth & Edward M. Scolnick

Authors
  1. Esther H. Chang
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  2. Mark E. Furth
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  3. Edward M. Scolnick
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  4. Douglas R. Lowy
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Chang, E., Furth, M., Scolnick, E. et al. Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus. Nature 297, 479–483 (1982). https://doi.org/10.1038/297479a0

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