Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

The structure of one of the eight or more distinct chromosomal genes for human interferon-α

Nature volume 287, pages 401–408 (1980)Cite this article

Abstract

The 12 Interferon (IFN)-related sequences detected in a human gene bank fall into not less than eight distinct classes, indicating that there are at least eight IFN-related genes. Most, if not all, of these direct the synthesis of an IFN in Escherichia coli. The sequence of one chromosomal gene and its flanking regions was identical to that deduced for the cDNA corresponding to IFN-αl mRNA. No evidence was found for the existence of an intron, in either the coding or the non-coding segments of the gene.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Nagata, S. et al. Nature 284, 316–320 (1980).

    Article  ADS  CAS  Google Scholar 

  2. Stewart, W. E. II et al. Nature 286, 110 (1980).

    Article  Google Scholar 

  3. Streuli, M., Nagata, S. & Weissmann, C. Science (in the press).

  4. Mantei, N. et al. Gene 10, 1–10 (1980).

    Article  CAS  Google Scholar 

  5. Zoon, K. C. et al. Science 207, 527–528 (1980).

    Article  ADS  CAS  Google Scholar 

  6. Lawn, R. M., Fritsch, E. E., Parker, R. C., Blake, G. & Maniatis, T. Cell 15, 1157–1174 (1978).

    Article  CAS  Google Scholar 

  7. Benton, W. D. & Davis, R. W. Science 196, 180–182 (1977).

    Article  ADS  CAS  Google Scholar 

  8. Maniatis, T. et al. Cell 15, 687–701 (1978).

    Article  CAS  Google Scholar 

  9. Southern, E. M. J. molec. Biol. 98, 503–517 (1975).

    Article  CAS  Google Scholar 

  10. Kafatos, F., Efstratiadis, A., Forget, B. & Weissmann, S. Proc. natn. Acad. Sci. U.S.A. 74, 5618–5622 (1977).

    Article  ADS  CAS  Google Scholar 

  11. Stewart, W. E. II & Sulkin, S. E. Proc. Soc. exp. Biol. Med. 123, 650–653 (1966).

    Article  CAS  Google Scholar 

  12. Mercereau-Puijalon, O. & Kourilsky, P. Nature 279, 647–649 (1979).

    Article  ADS  CAS  Google Scholar 

  13. Villa-Komaroff, L. et al. Proc. natn. Acad. Sci. U.S.A. 75, 3727–3731 (1978).

    Article  ADS  CAS  Google Scholar 

  14. Efstratiadis, A., Kafatos, F. C., Maxam, A. M. & Maniatis, T. Cell 7, 279–288 (1976).

    Article  CAS  Google Scholar 

  15. Richards, R. I., Shine, J., Ullrich, A., Wells, J. R. E. & Goodman, H. M. Nucleic Acids Res. 7, 1137–1146 (1976).

    Article  Google Scholar 

  16. Tsujimoto, Y. & Suzuki, Y. Cell 18, 591–600 (1979).

    Article  CAS  Google Scholar 

  17. Maxam, A. M. & Gilbert, W. Proc. natn. Acad. Sci. U.S.A. 74, 560–564 (1977).

    Article  ADS  CAS  Google Scholar 

  18. Weaver, R. F. & Weissmann, C. Nucleic Acids Res. 7, 1175–1193 (1979).

    Article  CAS  Google Scholar 

  19. Baralle, F. E. & Brownlee, G. G. Nature 274, 84–87 (1978).

    Article  ADS  CAS  Google Scholar 

  20. Lomedico, P. et al. Cell 18, 545–558 (1979).

    Article  CAS  Google Scholar 

  21. Goldberg, M. thesis, Stanford Univ. (1979).

  22. Schaffner, W. et al. Cell 14, 655–671 (1978).

    Article  CAS  Google Scholar 

  23. Gannon, F. et al. Nature 278, 428–434 (1979).

    Article  ADS  CAS  Google Scholar 

  24. Cochet, M. et al. Nature 282, 567–574 (1979).

    Article  ADS  CAS  Google Scholar 

  25. Wahli, W., Dawid, I. B., Wyler, T., Weber, R. & Ryffel, G. U. Cell 20, 107–117 (1980).

    Article  CAS  Google Scholar 

  26. Volckaert, G., Feunteun, J., Crawford, L. V., Berg, P. & Fiers, W. J. Virol. 30, 674–682 (1979).

    CAS  PubMed  PubMed Central  Google Scholar 

  27. Gruss, P., Lai, C.-J., Dhar, R. & Khoury, G. Proc. natn. Acad. Sci. U.S.A. 76, 4317–4321 (1979).

    Article  ADS  CAS  Google Scholar 

  28. Hamer, D. H. & Leder, P. Cell 18, 1299–1302 (1979).

    Article  CAS  Google Scholar 

  29. Aleström, P. et al. Cell 19, 671–681 (1980).

    Article  Google Scholar 

  30. Parsons, J. T., Coffin, J. M., Haroz, R. K., Bromley, P. A. & Weissmann, C. J. Virol. 11, 761–774 (1973).

    CAS  PubMed  PubMed Central  Google Scholar 

  31. Bishop, J. M. A. Rev. Biochem. 47, 35–88 (1978).

    Article  CAS  Google Scholar 

  32. Vennström, B., Persson, H., Pettersson, U. & Philipson, L. Nucleic Acids Res. 7, 1405–1418 (1979).

    Article  Google Scholar 

  33. Mandel, J. L. et al. Cell 14, 641–653 (1978).

    Article  CAS  Google Scholar 

  34. Hardison, R. C., Butler, E. T. III, Lacy, E. & Maniatis, T. Cell 18, 1285–1297 (1979).

    Article  CAS  Google Scholar 

  35. Lauer, J., Shen, C.-K. J. & Maniatis, T. Cell 20, 119–130 (1980).

    Article  CAS  Google Scholar 

  36. Taniguchi, T. et al. Nature 285, 547–549 (1980).

    Article  ADS  CAS  Google Scholar 

  37. Taniguchi, T., Ohno, S., Fujii-Kuriyama, Y. & Muramatsu, M. Gene 10, 11–15 (1980).

    Article  CAS  Google Scholar 

  38. Derynck, R. et al. Nature 285, 542–547 (1980).

    Article  ADS  CAS  Google Scholar 

  39. Houghton, M. et al. Nucleic Acids Res. 8, 2885–2894 (1980).

    Article  CAS  Google Scholar 

  40. Nishioka, Y., Leder, A. & Leder, P. Proc. natn. Acad. Sci. U.S.A. 77, 2806–2809 (1980).

    Article  ADS  CAS  Google Scholar 

  41. Rubinstein, M. et al. Proc. natn. Acad. Sci. U.S.A. 76, 640–644 (1979).

    Article  ADS  CAS  Google Scholar 

  42. Weatherall, D. J. & Clegg, J. B. Cell 16, 467–479 (1979).

    Article  CAS  Google Scholar 

  43. Fritsch, E. F., Lawn, R. M. & Maniatis, T. Cell 19, 959–972 (1979).

    Article  Google Scholar 

  44. Weldon Jones, C. & Kafatos, F. C. Nature 284, 635 (1980).

    Article  ADS  Google Scholar 

  45. Spradling, A. C., Digan, M. E., Mahowald, A. P., Scott, M. & Craig, E. A. Cell 19, 905–911 (1980).

    Article  CAS  Google Scholar 

  46. Kindle, K. L. & Firtel, R. A. Cell 15, 763–778 (1978).

    Article  CAS  Google Scholar 

  47. Stewart, W. E. II et al. Gene (in the press).

  48. Masucci, M. G. et al. Science (in the press).

  49. Stewart, W. E. II in The Interferon System (Springer, Vienna-New York, 1980).

    Google Scholar 

  50. Jeffreys, A. J. & Flavell, R. A. Cell 12, 429–439 (1977).

    Article  CAS  Google Scholar 

  51. Blattner, F. et al. Science 196, 161–169 (1977).

    Article  ADS  CAS  Google Scholar 

  52. Fried, M. et al. Nature 279, 811–816 (1979).

    Article  ADS  CAS  Google Scholar 

  53. Hanahan, D. & Meselson, M. Gene 10, 63–67 (1980).

    Article  CAS  Google Scholar 

  54. Wilkie, N. M. et al. Nucleic Acids Res. 7, 859–877 (1979).

    Article  CAS  Google Scholar 

  55. Smith, H. O. & Birnstiel, M. L. Nucleic Acids Res. 3, 2387–2398 (1976).

    Article  CAS  Google Scholar 

  56. Müller, W., Weber, H., Meyer, F. & Weissmann, C. J. molec. Biol. 124, 343–358 (1978).

    Article  Google Scholar 

  57. Peacock, A. C. & Dingman, C. W. Biochemistry 6, 1818–1827 (1967).

    Article  CAS  Google Scholar 

  58. Wiegand, R. C., Godson, G. N. & Radding, C. M. J. biol. Chem. 250, 8845–8855 (1975).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut für Molekularbiologie I, Universität Zürich, 8093, Zürich, Switzerland

    Shigekazu Nagata, Ned Mantei & Charles Weissmann

Authors
  1. Shigekazu Nagata
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ned Mantei
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Charles Weissmann
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nagata, S., Mantei, N. & Weissmann, C. The structure of one of the eight or more distinct chromosomal genes for human interferon-α. Nature 287, 401–408 (1980). https://doi.org/10.1038/287401a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/287401a0

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing