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Coated pits, coated vesicles, and receptor-mediated endocytosis

Nature volume 279, pages 679–685 (1979)Cite this article

Abstract

Proteins and peptides can enter cells by receptor-mediated endocytosis, a coupled process by which selected extracellular proteins or peptides are first bound to specific cell surface receptors and then rapidly internalised by the cell Internalisation follows clustering of the receptors in specialised regions of the cell surface called coated pits that invaginate to form intracellular coated vesicles. It is now recognised that receptor-mediated endocytosis has a fundamental role in the growth, nutrition and differentiation of animal cells.

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Authors and Affiliations

  1. Departments of Molecular Genetics and Cell Biology, University of Texas Health Science Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas, 75235

    Joseph L. Goldstein, Richard G. W. Anderson & Michael S. Brown

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Goldstein, J., Anderson, R. & Brown, M. Coated pits, coated vesicles, and receptor-mediated endocytosis. Nature 279, 679–685 (1979). https://doi.org/10.1038/279679a0

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