Abstract
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects a large proportion of the elderly population. Amyloid plaques, which are a neuro-pathological characteristic of AD, have been reproduced in transgenic mice by the overexpression of mutant forms of the amyloid-β precursor protein (APP) known to cause familial AD. Here we report that these mice exhibit selective neuronal death in the brain regions that are most affected in AD, suggesting that amyloid plaque formation is directly involved in AD neuron loss.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Sturchler-Pierrat, C.et al. Proc. Natl Acad. Sci. USA 94, 13287–13292 (1997).
West, M. J., Coleman, P. D., Flood, D. G. & Troncoso, J. C. Lancet 344, 769–772 (1994).
Regeur, L., Jensen, G. B., Pakkenberg, H., Evans, S. M. & Pakkenberg, B. Neurobiol. Aging 15, 347–352 (1994).
Gomez-Isla, T.et al. J. Neurosci. 16, 4491–4500 (1996).
Pakkenberg, B. & Gundersen, H. J. J. Comp. Neurol. 384, 312–320 (1997).
Calhoun, M. E. et al. (in the press).
Games, D. et al. Nature 373, 523-527 (1995).
Hsiao, K.et al. Science 274, 99–102 (1996).
Irizarry, M. C.et al. J. Neurosci. 17, 7053–7059 (1997).
Irizarry, M. C., McNamara, M., Fedorchak, K., Hsiao, K. & Hyman, B. T. J. Neuropathol. Exp. Neurol. 56, 965–973 (1997).
Mattson, M. P.et al. Neuron 10, 243–254 (1993).
Jucker, M. & Ingram, D. K. Behav. Brain Res. 85, 1–26 (1997).
Geula, C. et al. Nature Med. 4, 827-831 (1998).
West, M. J. Neurobiol. Aging 14, 275–285 (1993).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Calhoun, M., Wiederhold, KH., Abramowski, D. et al. Neuron loss in APP transgenic mice. Nature 395, 755–756 (1998). https://doi.org/10.1038/27351
Issue Date:
DOI: https://doi.org/10.1038/27351
This article is cited by
-
Critical thinking of Alzheimer’s transgenic mouse model: current research and future perspective
Science China Life Sciences (2023)
-
An App knock-in rat model for Alzheimer’s disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairments
Cell Research (2022)
-
Endoplasmic reticulum stress contributes to the decline in doublecortin expression in the immature neurons of mice with long-term obesity
Scientific Reports (2022)
-
Lesions without symptoms: understanding resilience to Alzheimer disease neuropathological changes
Nature Reviews Neurology (2022)
-
α-Enolase reduces cerebrovascular Aβ deposits by protecting Aβ amyloid formation
Cellular and Molecular Life Sciences (2022)
