One of the most versatile and universal signalling agents in the human body is the calcium ion, Ca2+. How does this simple ion act during cell birth, life and death, and how does it regulate so many different cellular processes?
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References
Berridge, M. J. Nature 361, 315–325 (1993).
Clapham, D. E. Cell 80, 259–268 (1995).
Bootman, M. D. & Berridge, M. J. Cell 83, 675–678 (1995).
Lipp, P. & Niggli, E. Prog. Biophys. Mol. Biol. 65, 265–296 (1996).
Berridge, M. J. J. Physiol., Lond. 499, 291–306 (1997).
Nelson, M. T. et al. Science 270, 633–637 (1995).
Porter, V. A. et al. Am. J. Physiol. 274, C1346-C1355 (1998).
Dolmetsch, R. E., Xu, K. & Lewis, R. S. Nature 392, 933–936 (1998).
De Koninck, P. & Schulman, H. Science 279, 227–230 (1998).
Dolmetsch, R. E., Lewis, R. S., Goodnow, C. C. & Healy, J. I. Nature 386, 855–858 (1997).
Swanson, C. A., Arkin, A. P. & Ross, J. Proc. Natl Acad. Sci. USA 94, 1194–1199 (1997).
Ciapa, B., Pesando, D., Wilding, M. & Whitaker, M. Nature 368, 875–878 (1994).
Ault, K. T., Durmowicz, G., Galione, A., Harger, P. L. & Busa, W. B. Development 122, 2033–2041 (1996).
Kume, S. et al. Science 278, 1940–1943 (1997).
Stusarski, D. C., Corces, V. G. & Moon, R. T. Nature 390, 410–413 (1997).
Ferrari, M. B., Rohrbough, J. & Spitzer, N. C. Dev. Biol. 178, 484–497 (1996).
de la Pompa, J. L. et al. Nature 392, 182–185 (1998).
Gu, X. & Spitzer, N. C. Nature 375, 784–787 (1995).
Komura, H. & Rakic, P. Neuron 17, 275–285 (1996).
Katz, L. C. & Shatz, C. J. Science 274, 1133–1138 (1996).
Berridge, M. J. BioEssays 17, 491–500 (1995).
Kohn, E. C. et al. Cancer Res. 56, 569–573 (1996).
Berridge, M. J. Neuron 21, 13–26 (1998).
Sugimori, M., Lang, E. J., Silver, R. B. & Llinas, R. Biol. Bull. 187, 300–303 (1994).
Bito, H., Deisseroth, K. & Tsien, R. W. Curr. Opin. Neurobiol. 7, 419–429 (1997).
Hardingham, G. E., Chawla, S., Johnson, C. M. & Bading, H. Nature 385, 260–265 (1997).
He, H., Lam, M., McCormick, T. S. & Distelhorst, C. W. J. Cell Biol. 138, 1219–1228 (1997).
Murphy, A. N., Bredesen, D. E., Cortopassi, G., Wang, E. & Fiskum, G. Proc. Natl Acad. Sci. USA 93, 9893–9898 (1996).
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Berridge, M., Bootman, M. & Lipp, P. Calcium - a life and death signal. Nature 395, 645–648 (1998). https://doi.org/10.1038/27094
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DOI: https://doi.org/10.1038/27094
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