Abstract
THERE is at present much interest in the herpes viruses because they have been associated with human cancer and cause latent infections with recurrent disease. They are also of interest because they form a relatively simple but apt model for the processes of transcription and DNA replication in eukaryotic cells. We have studied the virus-induced proteins involved in DNA replication, and present here results that give definitive evidence that the virus-induced DNA polymerase is encoded in the virus genome, that locate the gene for virus DNA polymerase, and also show that the enzyme is essential for virus replication.
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PURIFOY, D., LEWIS, R. & POWELL, K. Identification of the herpes simplex virus DNA polymerase gene. Nature 269, 621–623 (1977). https://doi.org/10.1038/269621a0
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DOI: https://doi.org/10.1038/269621a0
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