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Endogenous opioid peptides: multiple agonists and receptors

Nature volume 267, pages 495–499 (1977)Cite this article

Abstract

Opioid peptides were assayed by inhibition of 3H-naloxone and 3H-leu-enkephalin binding in brain homogenates and by depression of contractions of the guinea pig ileum and mouse vas deferens. We conclude that the opioid peptidergic system has agonists of different characteristics which interact with more than one type of receptor.

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Authors and Affiliations

  1. Unit for Research on Addictive Drugs, University of Aberdeen, Marischal College, Aberdeen, UK

    John A. H. Lord, Angela A. Waterfield, John Hughes & Hans W. Kosterlitz

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  1. John A. H. Lord
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  2. Angela A. Waterfield
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  3. John Hughes
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  4. Hans W. Kosterlitz
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Lord, J., Waterfield, A., Hughes, J. et al. Endogenous opioid peptides: multiple agonists and receptors. Nature 267, 495–499 (1977). https://doi.org/10.1038/267495a0

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