Abstract
WE have previously shown that polio-l-virus, when propagated in HeLa cells in the presence of guanidine hydrochloride, can become resistant to guanidine, and, after a number of additional transfers, will become dependent on guanidine1–3.
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LODDO, B., MUNTONI, S., SPANEDDA, A. et al. Guanidine Conditioned Infectivity of Ribonucleic Acid extracted from a Strain of Guanidine-dependent Polio-l-Virus. Nature 197, 315 (1963). https://doi.org/10.1038/197315a0
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DOI: https://doi.org/10.1038/197315a0
