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In vitro Inhibition of Infectivity of Polio Viruses by Guanidine

Nature volume 193, pages 97–98 (1962)Cite this article

Abstract

THE presence of a guanidine moiety in a number of antiviral drugs1–5 prompted us to investigate whether some simple guanidine derivatives may reduce the infectivity of viruses for cultured mammalian cells. The following compounds were examined: guanidine hydrochloride, aminoguanidine bicarbonate, creatine hydrate, arginine, uridine, urea, thiourea, decyl- and dodecyl-bis-guanidine, N,N′-bis(beta-hydroxyethyl)biguanide. The chemicals dissolved in water were boiled for about 15 min. and then added to the culture media.

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Authors and Affiliations

  1. Departments of Pharmacology, of Hygiene and of Microbiology, University of Cagliari, Italy

    B. LODDO, W. FERRARI, G. BROTZU & A. SPANEDDA

Authors
  1. B. LODDO
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  2. W. FERRARI
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  3. G. BROTZU
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  4. A. SPANEDDA
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LODDO, B., FERRARI, W., BROTZU, G. et al. In vitro Inhibition of Infectivity of Polio Viruses by Guanidine. Nature 193, 97–98 (1962). https://doi.org/10.1038/193097a0

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