REFERENCES
S. Hirai, T. Ikenaga, and T. Matsuzawa. Nasal absorption of insulin in dogs, Diabetes. 27:296-299 (1978).
G. C. Y. Chiou, C. Chuang, and M. S. Chang. Reduction of blood glucose concentration with insulin eyedrops, Diabetes Care. 11:750-751 (1988).
D. J. Pillion, J. D. Bartlett, E. Meezan, M. Yang, R. J. Crain, and W. E. Grizzle. Systemic absorption of insulin delivered topically to the rat eye, Invest. Ophthalmol. Vis. Sci. 32:3021-3027 (1991).
D. J. Pillion, J. A. Atchison, J. Stott, D. L. McCracken, C. Garguilo, and E. Meezan. Efficacy of insulin eyedrops, J. Ocul. Pharmacol. 10:461-470 (1994).
A. C. Moses, G. S. Gordon, M. C. Carey, and J. S. Flier. Insulin administered intranasally as an insulin-bile salt aerosol. Effectiveness and reproducibility in normal and diabetic subjects, Diabetes. 32:1040-1047 (1983).
J. Hilsted, S. Madsbad, A. Hvidberg, et al. Intranasal insulin therapy: the clinical realities, Diabetologia. 38:680-684 (1995).
K. Dreyer, A. Vaag, K. Bech, P. Hansen, A. R. Sorensen, and N. Mygind. Intranasal administration of insulin with phospholipid as absorption enhancer: Pharmacokinetics in normal subjects, Diab. Med. 9:335-340 (1992).
B. J. Aungst, A. J. Rogers, and E. Shefter. Comparison of nasal, rectal, sublingual and intramuscular insulin efficacy and the effects of a bile salt absorption promotor, J. Pharmacol. Exp. Therap. 244:23-27 (1988).
D. J. Pillion, J. A. Atchison, C. Garguilo, J. Stott, P. Wang, and E. Meezan. Insulin delivery in nosedrops: New formulations containing alkylglycosides, Endocrinology. 135:1386-1391 (1994).
D. J. Pillion, P. Wang, J. Yorks, P. McCann, and E. Meezan. Systemic absorption of insulin and glucagon applied to the eyes of rats and a diabetic dog, J. Ocul. Pharmacol. Tox. 11:283-295 (1995).
D. J. Pillion, J. A. Atchison, and E. Meezan. Alkylglycosides enhance systemic absorption of insulin applied topically to the rat eye, J. Pharmacol. Exp. Therap. 271:1274-1280 (1994).
D. J. Pillion, D. L. McCracken, M. Yang, and J. A. Atchison. Glucagon administration to the rat via eyedrops, J. Ocul. Pharmacol. 8:349-358 (1992).
D. C. Howey, R. R. Bowsher, R. L. Brunelle, and J. R. Woodworth. [Lys(B28),Pro(B29)]-human insulin: a rapidly absorbed analog of human insulin, Diabetes. 43:396-402 (1994).
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Pillion, D.J., Hosmer, S. & Meezan, E. Dodecylmaltoside-Mediated Nasal and Ocular Absorption of Lyspro-Insulin: Independence of Surfactant Action from Multimer Dissociation. Pharm Res 15, 1637–1639 (1998). https://doi.org/10.1023/A:1011975721569
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DOI: https://doi.org/10.1023/A:1011975721569