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Control of Locomotor Activity in Humans and Animals in the Absence of Supraspinal Influences

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Abstract

Electrical epidural stimulation of the dorsal surface of the spinal cord at the level of the second lumbar segment induced step-like movements accompanied by the corresponding electromyographic activity in the leg muscles in patients lacking supraspinal influences as a result of vertebral trauma. Triggering of stepping movements was shown to occur with particular stimulation parameters. The results provide evidence that in humans, as in other mammals, the spinal cord contains a network of interneurons acting as generators of stepping movements and producing coordinated patterns of movement activity. Experiments on chronic spinal cats demonstrated the leading role of the propriospinal system of the spinal cord in activating the spinal generators of stepping in response to epidural stimuli.

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REFERENCES

  1. O. V. Kazennikov, M. L. Shik, and G. V. Yakovleva, “Stepping movements induced by stimulation of the dorsolateral column of the spinal cord in the cat,” Byull. Éksp. Biol. Med., 96, 8-10 (1983).

    Google Scholar 

  2. O. V. Kazennikov and M. L. Shik, “Distribution of activity along the 'stepping strip' of the spinal cord of the cat,” Neirofiziologiya, 20, 763-769 (1988).

    Google Scholar 

  3. G. N. Orlovskii, “Connections of reticulospinal neurons with the 'locomotor strip' of the brainstem,” Biofizika, 15, 171-177 (1970).

    Google Scholar 

  4. A. Makarovskii, A. Garbuz, Yu. Shapkov, and Yu. Gerasimenko, “An apparatus for the diagnosis and electrical stimulation of spinal cord structures,” Patent Application No. 1832515, 13 October 1992.

  5. A. N. Makarovskii, A. E. Garbuz, and Yu. P. Gerasimenko, “An electrode 'fan' for implantation into the anterior surface of the dura mater of the spinal cord,” Patent No. 97119571, 3 December 1997.

  6. M. L. Shik, F. V. Severin, and G. N. Orlovskii, “Control of gait and running by electrical stimulation of the midbrain,” Biofizika, 11, 659-666 (1966).

    Google Scholar 

  7. A. Bayoumi and A. Ashby, “Projections of group Ia afferents to motoneurons of thigh muscles in man,” Exptl. Brain. Res., 76, 223-228 (1989).

    Google Scholar 

  8. V. G. T. Beusekom, Fibre Analysis of the Anterior and Lateral Funiculi of the Cord in the Cat, Eduard Ijdo, Leiden (1956).

    Google Scholar 

  9. B. Coburn and W. K. Sin, “A theoretical study of epidural electrical stimulation of the spinal cord. Part I. Finite element analysis of stimulus fields,” IEEE Trans. Biomed. Eng., 32, 971-977 (1985).

    Google Scholar 

  10. M. Dmitrijevic, Yu. Gerasimenko, and M. Pinter, “Evidence for a spinal central pattern generator in humans,” Ann. N.Y. Acad. Sci., 860, 360-376 (1998).

    Google Scholar 

  11. S. Grillner and P. Zangger, “How detailed is the central pattern generation for locomotion?” Brain Res., 88, 367-371 (1975).

    Google Scholar 

  12. J. P. Hunter and P. Ashby, “Segmental effects of epidural spinal cord stimulation in humans,” J. Physiol. (London), 474, 407-419 (194).

    Google Scholar 

  13. E. Jankowska, I. Riddel, B. Skoog, and B. Noga, “Gating of transmission to motoneurones by stimulation applied in the locus coeruleus and raphe nuclei of the cat,” J. Physiol. (London), 461, 705-722 (1993).

    Google Scholar 

  14. D. P. C. Lloyd and A. K. McIntyre, “Dorsal column conduction of group in muscle afferent impulses and their relay through Clarke's column,” J. Neurophysiol., 13, No. 1, 39-54 (1950).

    Google Scholar 

  15. K. Matsuyama, F. Mori, and S. Mori, “Fine structure of a reticulospinal-interneuronal system for coordinating locomotor rhythm in cats,” in: From Basic Motor Control to Functional Recovery, N. Gantchev and G. Gantchev (eds.), Varna (1999), pp. 14-18.

  16. B. Rexed, “Some aspects of cytoarchitectonics and synaptology of the spinal cord,” Progr. Brain Res., 2, 58-92 (1964).

    Google Scholar 

  17. H. E. Roaf and C. S. Sherrington, “Further remarks on the spinal mammalian preparation,” Quart. J. Physiol., 3, 209-211 (1910).

    Google Scholar 

  18. C. S. Sherrington, “Flexion-reflex of the limb, crossed extension-reflex, and reflex stepping and standing,” J. Physiol. (London), 40, 28-121 (1910).

    Google Scholar 

  19. M. L. Shik, “Recognizing propriospinal and reticulospinal systems of initiation of stepping,” Motor Control, 1, 310-313 (1997).

    Google Scholar 

  20. J. S. Steeves and L. M. Jordan, “Localization of a descending pathway in the spinal cord which is necessary for controlled treadmill locomotion,” Neurosci. Lett., 20, 283-288 (1980).

    Google Scholar 

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Authors and Affiliations

  1. Laboratory for Movement Physiology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, 6 Makarov Bank, 199034, St. Petersburg, Russia

    Yu. P. Gerasimenko & O. A. Nikitin

  2. Department of Vertebral Surgery, Institute of Phthysiopulmonology, Ministry of Health of the Russian Federation, 32 Politekhnicheskaya Street, 194064, St. Petersburg, Russia

    A. N. Makarovskii

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  1. Yu. P. Gerasimenko
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  2. A. N. Makarovskii
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  3. O. A. Nikitin
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Gerasimenko, Y.P., Makarovskii, A.N. & Nikitin, O.A. Control of Locomotor Activity in Humans and Animals in the Absence of Supraspinal Influences. Neurosci Behav Physiol 32, 417–423 (2002). https://doi.org/10.1023/A:1015836428932

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