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Genetic Epidemiology of Psoriasis

  • Epidemiology (A Armstrong, Section Editor)
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Abstract

Psoriasis is a chronic, inflammatory, immune-mediated skin condition with a prevalence of 0–11.8 % across the world. It is associated with a number of cardiovascular, metabolic, and autoimmune disease comorbidities. Psoriasis is a multifactorial disorder, influenced by both genetic and environmental factors. Its genetic basis has long been established through twin studies and familial clustering. The association of psoriasis with the HLA-Cw6 allele has been shown in many studies. Recent genome-wide association studies have identified a large number of other genes associated with psoriasis. Many of these genes regulate the innate and adaptive immune system. These findings indicate that a dysregulated immune system may play a major role in the pathogenesis of psoriasis. In this article, we review the clinical and genetic epidemiology of psoriasis with a brief description of the pathogenesis of disease.

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M. Debbaneh declares no conflict of interest.

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  1. Department of Dermatology, University of California, San Francisco, 2340 Sutter Street, San Francisco, CA, 94143, USA

    Rashmi Gupta, Maya G. Debbaneh & Wilson Liao

  2. School of Medicine, University of California, Irvine, Irvine, CA, USA

    Maya G. Debbaneh

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Gupta, R., Debbaneh, M.G. & Liao, W. Genetic Epidemiology of Psoriasis. Curr Derm Rep 3, 61–78 (2014). https://doi.org/10.1007/s13671-013-0066-6

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