Abstract
Pseudo-vascular adenoid squamous cell carcinoma (PASCC) is an uncommon histological variant. It is characterized by an acantholysis of the tumor cells and the formation of anastomosing spaces and channels. It gives a false appearance of glandular differentiation mimicking angiosarcoma. PASCC has been reported in the head and neck, as well as in other organs like the breast, lungs, urinary bladder, vulva, and the uterine cervix. We report a case of PASCC of the oral cavity in a recently operated case of squamous cell carcinoma of the buccal mucosa.


Similar content being viewed by others
References
Qi XP, Lin GB, Zhu YL, Wang JQ, Dai XW, Ma JM, Yan L (2009) Pseudoangiosarcomatous squamous cell carcinoma of the penis: a case report with clinicopathological and human papillomavirus analyses. Zhonghua nan kexue=. Natl J Androl 15(2):134–139
Zidar N, Gale N, Zupevc A, Dovšak D (2006) Pseudovascular adenoid squamous-cell carcinoma of the oral cavity—a report of two cases. J Clin Pathol 59(11):1206–1208
Horn LC, Liebert UG, Edelmann J, Höckel M, Einenkel J (2008) Adenoid squamous carcinoma (pseudoangiosarcomatous carcinoma) of the vulva: a rare but highly aggressive variant of squamous cell carcinoma-report of a case and review of the literature. Int J Gynecol Pathol 27(2):288–291
Vidyavathi K, Prasad CS, Kumar HM, Deo RP (2012) Pseudovascular adenoid squamous cell carcinoma of the oral cavity: a mimicker of angiosarcoma. J Oral Maxillofac Pathol 16(2):288–290
Kong M, Ren X, You Q, Yao H, Teng X (2011) Pseudoangiosarcomatous squamous cell carcinoma of the lung. J Int Med Res 39(4):1546–1554
Bánkfalvi A, Kraßort M, Buchwalow IB, Végh A, Felszeghy E, Piffkó J (2002) Gains and losses of adhesion molecules (CD44, E-cadherin, and β-catenin) during oral carcinogenesis and tumor progression. J Pathol 198(3):343–351
Wijnhoven BP, Dinjens WN, Pignatelli M (2000) E-cadherin-catenin cell-cell adhesion complex and human cancer. Br J Surg 87(8):992–1005
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Consent
Consent taken for publishing images.
Conflict of Interest
The authors declare no conflict of interest.
Institutional Review Board Approval
Taken.
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Vivek, V., Nandy, K., Bhatt, S. et al. Pseudovascular Adenoid Squamous Cell Carcinoma of Buccal Mucosa—a Rare Aggressive Variant. Indian J Surg Oncol 12, 311–314 (2021). https://doi.org/10.1007/s13193-021-01335-3
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13193-021-01335-3