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Chemokines and Their Receptors in the Allergic Airway Inflammatory Process

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Abstract

The development of the allergic airway disease conveys several cell types, such as T-cells, eosinophils, mast cells, and dendritic cells, which act in a special and temporal synchronization. Cellular mobilization and its complex interactions are coordinated by a broad range of bioactive mediators known as chemokines. These molecules are an increasing family of small proteins with common structural motifs and play an important role in the recruitment and cell activation of both leukocytes and resident cells at the allergic inflammatory site via their receptors. Trafficking and recruitment of cell populations with specific chemokines receptors assure the presence of reactive allergen-specific T-cells in the lung, and therefore the establishment of an allergic inflammatory process. Different approaches directed against chemokines receptors have been developed during the last decades with promising therapeutic results in the treatment of asthma. In this review we explore the role of the chemokines and chemokine receptors in allergy and asthma and discuss their potential as targets for therapy.

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Acknowledgments

This work was supported by Biomedicine in the Post-genomic Era A.C. The style review of the manuscript by Ms. Maggie Brunner, Coordinación de Investigación en Salud, IMSS, is greatly appreciated.

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  1. Unidad de Investigación Médica Zacatecas, Instituto Mexicano del Seguro Social, Zacatecas City, Mexico

    Juan Raymundo Velazquez

  2. Depart. Invest. Inmunogenética y Alergia, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico

    Luis Manuel Teran

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Correspondence to Juan Raymundo Velazquez.

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Velazquez, J.R., Teran, L.M. Chemokines and Their Receptors in the Allergic Airway Inflammatory Process. Clinic Rev Allerg Immunol 41, 76–88 (2011). https://doi.org/10.1007/s12016-010-8202-6

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