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Targeting regulatory T cells

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Abstract

Cancers express tumor-associated antigens that should elicit immune response to antagonize the tumor growth, but spontaneous immune rejection of established cancer is rare, suggesting an immunosuppressive environment hindering host antitumor immunity. Among the specific and active tumor-mediated mechanisms, CD4+CD25high T regulatory cells (Treg) are important mediators of active immune evasion in cancer. In this review, we will discuss Treg subpopulations and the mechanisms of their suppressive functions. Treg depletion improves endogenous antitumor immunity and the efficacy of active immunotherapy in animal models for cancer, suggesting that inhibiting Treg function could also improve the limited successes of human cancer immunotherapy. We will also discuss specific strategies for devising effective cancer immunotherapy targeting Treg.

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Authors and Affiliations

  1. Université de Lyon, F-69000, Lyon, France

    Christine Ménétrier-Caux, Julien Faget, Manuarii Manuel & Christophe Caux

  2. Université Lyon 1, ISPB, F-69008, Lyon, France

    Christine Ménétrier-Caux, Julien Faget, Manuarii Manuel & Christophe Caux

  3. Team 11, CRCL INSERM U-1052/CNRS5286, F-69008, Lyon, France

    Christine Ménétrier-Caux, Julien Faget, Manuarii Manuel & Christophe Caux

  4. LabEx DEVweCAN, Centre Léon Bérard, F-69008, Lyon, France

    Christine Ménétrier-Caux, Julien Faget, Manuarii Manuel & Christophe Caux

  5. Cancer Therapy and Research Center, Department of Medicine, UTHSCSA, San Antonio, TX, USA

    Tyler Curiel

  6. University of Michigan Department of Surgery and Cancer Center, Graduate programs in Immunology and Cancer Biology, C558 MSRBII, Ann Arbor, MI, 48109-5669, USA

    Weiping Zou

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  1. Christine Ménétrier-Caux
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Ménétrier-Caux, C., Curiel, T., Faget, J. et al. Targeting regulatory T cells. Targ Oncol 7, 15–28 (2012). https://doi.org/10.1007/s11523-012-0208-y

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