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Genetic variability in the sapovirus capsid protein

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Abstract

Sapovirus (SV), which causes gastroenteritis in humans, is composed of genetically divergent viruses classified into 5 genogroups. In this study, 2.2-kb nucleotide sequences of the 3′ terminus of the genome of 15 SV strains detected in Japan were determined. The 15 SV strains could be classified into four genogroups (GI, GII, GIV and GV), and in two of these, GI and GII, 10 genotypes were identified. The amino acid sequences of the central variable region of the capsid protein showed less than 81% identity when strains belonging to different genotypes were compared. It was therefore supposed that antigenic variety exists between different genotypes. These results will be useful for further genetic and antigenic analyses of SV.

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Acknowledgements

This work was supported in part by a Grant for Research on Re-emerging Infectious Diseases from The Ministry of Health, Labor and Welfare, Japan. We thank Hideki Ooya, Ishikawa Prefectural Institute of Public Health and Environmental Science, for kindly providing the SV-positive specimens. We also thank Naokazu Takeda (National Institute of Infectious Diseases) for suggestions and critical review of the manuscript.

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Authors and Affiliations

  1. Division of Virology, Chiba Prefectural Institute of Public Health, 666-2, Nitona-cho, Chuo-ku, Chiba-shi, Chiba, 260-8715, Japan

    Mineyuki Okada, Tomoko Ogawa, Ikuo Kaiho & Kuniko Shinozaki

  2. Microbiology Division, Ehime Prefecture institute of Public Health and Environmental Science, Ehime, 790-0003, Japan

    Yasutaka Yamashita & Mitsuaki Oseto

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  1. Mineyuki Okada
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  2. Yasutaka Yamashita
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  3. Mitsuaki Oseto
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  4. Tomoko Ogawa
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  5. Ikuo Kaiho
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  6. Kuniko Shinozaki
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Correspondence to Mineyuki Okada.

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Okada, M., Yamashita, Y., Oseto, M. et al. Genetic variability in the sapovirus capsid protein. Virus Genes 33, 157–161 (2006). https://doi.org/10.1007/s11262-005-0051-7

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  • DOI: https://doi.org/10.1007/s11262-005-0051-7

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