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Transgenic Modifications of the Rat Genome

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Abstract

The laboratory rat (R. norvegicus) is a very important experimental animal in several fields of biomedical research. This review describes the various techniques that have been used to generate transgenic rats: classical DNA microinjection and more recently described techniques such as lentiviral vector-mediated DNA transfer into early embryos, sperm-mediated transgenesis, embryo cloning by nuclear transfer and germline mutagenesis. It will also cover techniques associated to transgenesis such as sperm cryopreservation, embryo freezing and determination of zygosity. The availability of several technologies allowing genetic manipulation in the rat coupled to genomic data will allow biomedical research to fully benefit from the rat as an experimental animal.

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  1. Séverine Ménoret

    Present address: UMR 6061 CNRS Université de Rennes 1, Rennes, IFR643, 35043, France

Authors and Affiliations

  1. Institut de Transplantation et de Recherche en Transplantation (ITERT), F-44093, Nantes, France

    Laurent Tesson, Séverine Ménoret, Séverine Rémy, Claire Usal & Ignacio Anegon

  2. Institut National de la Santé et de la Recherche Médicale (INSERM), F-44093, U643 Nantes, France

    Laurent Tesson, Séverine Ménoret, Séverine Rémy, Claire Usal & Ignacio Anegon

  3. genOway, Lyon, France

    Jean Cozzi & Alexandre Fraichard

  4. INSERM U643-ITERT, 30, bal. J., Nantes, 44093, Monnet, France

    Ignacio Anegon

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  1. Laurent Tesson
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Correspondence to Ignacio Anegon.

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Tesson, L., Cozzi, J., Ménoret, S. et al. Transgenic Modifications of the Rat Genome. Transgenic Res 14, 531–546 (2005). https://doi.org/10.1007/s11248-005-5077-z

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