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Na+, K+ ATPase Activity Is Reduced in Amygdala of Rats with Chronic Stress-Induced Anxiety-Like Behavior

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Abstract

In this study, we examined the effects of two chronic stress regimens upon anxiety-like behavior, Na+, K+-ATPase activity and immunocontent, and oxidative stress parameters (antioxidant enzymes and reactive oxygen species production) in the amygdala. Male rats were subjected to chronic unpredictable and to chronic restraint stress for 40 days. Subsequently, anxiety-like behavior was examined. Both stressed groups presented increased anxiety-like behavior. Reduced amygdalal Na+, K+-ATPase activity in the synaptic plasma membranes was also observed, without alterations in the amygdala immunocontent. In addition, when analyzing oxidative stress parameters, only superoxide dismutase activity was decreased in the amygdala of animals subjected to unpredictable stress. We conclude that both models of chronic stress lead to anxiety-like behavior and decreased amygdalal Na+, K+-ATPase activity, which appears not to be related to oxidative imbalance. The relationship between this decreased activity and anxiety-like behavior remains to be studied.

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Acknowledgments

This work was supported by the National Research Council of Brazil (CNPq), and FINEP/Rede IBN 01.06.0842-00. Leonardo M. Crema was the recipient of a CNPq fellowship.

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  1. Departamento de Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos, 2600, Anexo, 90035-003, Porto Alegre, RS, Brazil

    Leonardo Crema, Michele Schlabitz, Bárbara Tagliari, Aline Cunha, Fabrício Simão, Rachel Krolow, Letícia Pettenuzzo, Christianne Salbego, Deusa Vendite, Angela T. S. Wyse & Carla Dalmaz

  2. Programa de Pós-Graduação em Neurociências, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

    Leonardo Crema, Deusa Vendite & Carla Dalmaz

  3. Programa de Pós-Graduação em Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

    Bárbara Tagliari, Fabrício Simão, Rachel Krolow, Letícia Pettenuzzo, Christianne Salbego, Angela T. S. Wyse & Carla Dalmaz

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  1. Leonardo Crema
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Crema, L., Schlabitz, M., Tagliari, B. et al. Na+, K+ ATPase Activity Is Reduced in Amygdala of Rats with Chronic Stress-Induced Anxiety-Like Behavior. Neurochem Res 35, 1787–1795 (2010). https://doi.org/10.1007/s11064-010-0245-9

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