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Exploration of SOD3 from gene to therapeutic prospects: a brief review

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Abstract

Superoxide dismutase 3 (SOD3) is a type of antioxidant enzyme, which plays an important role in converting superoxide anion into hydrogen peroxide through its extracellular activity. This enzyme has been widely studied and evaluated from various points of view, including maintaining cellular redox balance, protecting against oxidative damage, and enhancing overall cellular resilience. The current paper focuses on SOD3 expression from a functional perspective. In addition to a detailed examination of the gene and protein structure, we found ample evidence indicating that the expression level of SOD3 undergoes alterations in response to various transcription factors, signaling pathways, and diverse conditions. These fluctuations, by disrupting the homeostasis of SOD3, can serve as crucial indicators of the onset or exacerbation of specific diseases. In this regard, significant efforts have been dedicated in recent years to the treatment of diseases through the regulation of SOD3 expression. The ultimate goal of this review is to extensively highlight and demonstrate the immense potential of SOD3 as a therapeutic target, emphasizing its profound impact on health outcomes.

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Acknowledgements

We sincerely thank Mr. Mohammad Yahya Karimi for proposing this project and for his invaluable assistance in improving the article’s figure. We also extend our appreciation to Mr. Nima Mohseni for his dedicated efforts in data collection.

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The authors did not receive support from any organization for the submitted work.

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  1. Department of Molecular and Cell Biology, Faculty of Science, University of Mazandaran, Babolsar, 47416-95447, Mazandaran, Iran

    Amin Kalmari & Abasalt Hosseinzadeh Colagar

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  1. Amin Kalmari
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Amin Kalmari contributed to the study conception, design and writing. Abasalt Hosseinzadeh Colagar provided supervision and critical revisions.

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Correspondence to Abasalt Hosseinzadeh Colagar.

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Kalmari, A., Colagar, A.H. Exploration of SOD3 from gene to therapeutic prospects: a brief review. Mol Biol Rep 51, 980 (2024). https://doi.org/10.1007/s11033-024-09919-2

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