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Hormone receptor-related gene polymorphisms and prostate cancer risk in North Indian population

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Abstract

The purpose of this study was to analyse the frequency and type of mutations in the coding region of androgen receptor (AR) and to determine the role of polymorphisms in the intron 1 of ERα, exon 5 of ERβ, intron 7 of progesterone, exon 7 of the aromatase (CYP19) and exon 9 of VDR genes in the risk of prostate cancer. PCR-RFLP analysis of all above the genes was on 100 prostate cancer patients and an equal number of matching controls. The study also included PCR-SSCP analyses of exons 2–8 of AR gene. The genotype containing −/− allele of ERα gene was statistically significant for the risk of prostate cancer pose (OR, 2.70; 95% CI, 1.08–6.70, P = 0.032) Rr genotype of ERβ gene also have a higher risk (OR, 1.65; 95% CI, 0.52–5.23) for prostate cancer. The Cys allele of CYP19 gene was also associated with statistically significant increased risk of prostate cancer (OR; 2.28, 95% CI, 1.20–4.35, P = 0.012). tt genotype of codon 352 of VDR gene showed an OR of 0.43 for (95% CI, 0.13–1.39) and an OR for Tt genotype was 0.65 (95% CI, 0.36–1.16). Taken together, the results showed that in North Indian population, ERα and CYP19 genes may be playing a role in the risk of prostate cancer.

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Authors and Affiliations

  1. Department of Biotechnology, Panjab University, Chandigarh, 160014, India

    Khadijeh Onsory, R. C. Sobti & Pushpinder Kaur

  2. Department of Biology, Basrah University, Al-Basrah, Iraq

    Adnan Issa Al-Badran

  3. Division of Materials Science and Chemical Engineering, Yokohama National University, Yokohama, Japan

    Masatoshi Watanabe

  4. Second Department of Pathology, Mie University School of Medicine, Tsu, Japan

    Taizo Shiraishi

  5. Division of Radiation Oncology and Experimental Therapeutics, University of Miami Medical School, Miami, FL, USA

    Awtar Krishan

  6. Department of Pathology, Government Medical College, Chandigarh, India

    Harsh Mohan

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  1. Khadijeh Onsory
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Onsory, K., Sobti, R.C., Al-Badran, A.I. et al. Hormone receptor-related gene polymorphisms and prostate cancer risk in North Indian population. Mol Cell Biochem 314, 25–35 (2008). https://doi.org/10.1007/s11010-008-9761-1

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  • DOI: https://doi.org/10.1007/s11010-008-9761-1

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